Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry

Filip S. Ekholm, I. Mándity, F. Fülöp, Reko Leino

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A rapid, simple, and efficient deprotection procedure for the deprotection of benzyl- and/or benzylidene protected carbohydrates is described utilizing a continuous flow hydrogenation reactor. The method tolerates both acid- and base sensitive functional groups. The high efficiency, simple work-up, and short reaction time should make this method appealing to researchers working in the fields of carbohydrate chemistry and total synthesis.

Original languageEnglish
Pages (from-to)1839-1841
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number16
DOIs
Publication statusPublished - Apr 20 2011

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Carbohydrates
Functional groups
Hydrogenation
Acids
Research Personnel

Keywords

  • Benzyl/benzylidene
  • Carbohydrates
  • Flow chemistry
  • Heterogenous catalysis
  • Protective groups

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry. / Ekholm, Filip S.; Mándity, I.; Fülöp, F.; Leino, Reko.

In: Tetrahedron Letters, Vol. 52, No. 16, 20.04.2011, p. 1839-1841.

Research output: Contribution to journalArticle

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