Rapid separation of some antiepileptic drugs in serum by HPLC

R. Ohmacht, Z. Matus, J. Soós

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A fast and easy, iscratic high-performance liquid chromatographic method for the simultaneous determination of primidone, phenobarbital, phenytoin, carbamazepine and thiobutabarbital from serum samples has been developed. The optimal eluent composition is 36% acetonitrile, 24% methanol and 40% phosphate buffer. Using a programmable wavelength detector very low (sub-therapeutic) levels of the drugs can be measured.

Original languageEnglish
Pages (from-to)85-86
Number of pages2
JournalChromatographia
Volume32
Issue number1-2
DOIs
Publication statusPublished - Jul 1 1991

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Keywords

  • Antiepileptic drugs
  • Column liquid chromatography
  • Optimised separation
  • Serum

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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