Rapid method to study the sedimentation of a pigment suspension prepared for coating fluids

János Bajdik, Éva Bölcskei, András Kelemen, Klára Pintye-Hódi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Film coating fluids commonly contain a pigment suspension. The sedimentation of insoluble particles in the coating suspension is one of the main problems during the formulation of the coating fluid. The aims of this work were to investigate the suitability of an energy-dispersive X-ray fluorescence analyser for rapid measurement of the sedimentation of titanium dioxide in aqueous suspensions. The suspensions were produced with a high-speed Ultra-Turrax. The process factors evaluated were the stirring rate, time and volume, and the process of sedimentation of the pigment. The enrichment of the pigment at the bottom of the sample holder was followed by means of the very rapid method of energy-dispersive X-ray fluorescence analysis. It can be concluded that the sedimentation of the particles is described by the Weibull equation. With an appropriate combination of the factors, a threefold increase in the sedimentation time was achieved. The mathematically based information (sedimentation time, kinetics of sedimentation, etc.) is essential for an exact evaluation of the preparation of the coating fluid. The understanding of the process through use of this test method leads to the ability to identify the critical control points of film coating.

Original languageEnglish
Pages (from-to)1159-1162
Number of pages4
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume44
Issue number5
DOIs
Publication statusPublished - Sep 3 2007

Keywords

  • Energy-dispersive X-ray fluorescence analysis
  • Factorial design
  • High-shear mixer
  • Pigment suspension
  • Sedimentation
  • Titanium dioxide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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