Rapid height growth after liver transplantation in adulthood

Balázs Szili, Dénes Görög, Zsuzsanna Gerlei, Gabriella Gyori, Péter Lakatos, I. Takács

Research output: Contribution to journalArticle

Abstract

Glycogen storage disease Ib is a rare, inherited metabolic disorder caused by glucose-6-phosphatase translocase deficiency. Its main symptoms are hypoglycemia, hyperlipidemia, neutropenia, hepatomegaly, liver adenomas and short stature. The exact mechanism of short stature in this disease is unclear, the most feasible possibility is that it is caused by impairment of growth-hormone and insulin-like growth factor I axis.Here we report the case of a patient who showed typical symptoms of glycogen storage disease Ib since his infancy, his height being under 1 percentile since then. Later-developed hypothyroidism and hypogonadism have also contributed to his short stature. Hypothyroidism was treated but sexual steroid substitution was not started because of an increased risk of hepatic adenomas.Because he developed hepatic adenoma at the age of 23, he had to undergo orthotopic liver transplantation. At the time of the transplantation his height was 128 cm. The transplantation was followed by rapid height growth; our patient's height reached 160.3 cm 62 months after transplantation. We observed that while his IGF-I level increased, his GH level remained unchanged. During the post-transplantation period we ensured adequate calcium and vitamin D supplementation, leaving hormonal substitution unchanged.According to our knowledge, this is the first report of a rapid height growth as big as 32 cm, of an individual over the age of 20, not related to endocrine treatment but liver transplantation.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalGrowth Hormone and IGF Research
Volume29
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Liver Transplantation
Transplantation
Adenoma
Glycogen Storage Disease
Growth
Hypothyroidism
Insulin-Like Growth Factor I
Liver
Glycogen Storage Disease Type I
Hepatomegaly
Hypogonadism
Hyperlipidemias
Neutropenia
Hypoglycemia
Vitamin D
Growth Hormone
Steroids
Calcium
Therapeutics

Keywords

  • Glycogen storage disease type Ib
  • Height growth in adult
  • Liver transplantation
  • Short stature

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Rapid height growth after liver transplantation in adulthood. / Szili, Balázs; Görög, Dénes; Gerlei, Zsuzsanna; Gyori, Gabriella; Lakatos, Péter; Takács, I.

In: Growth Hormone and IGF Research, Vol. 29, 01.08.2016, p. 1-3.

Research output: Contribution to journalArticle

Szili, Balázs ; Görög, Dénes ; Gerlei, Zsuzsanna ; Gyori, Gabriella ; Lakatos, Péter ; Takács, I. / Rapid height growth after liver transplantation in adulthood. In: Growth Hormone and IGF Research. 2016 ; Vol. 29. pp. 1-3.
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