We studied rapid changes in location of cyclic GMP in Tetrahymena pyriformis. Insulin caused cGMP localization in cilia and near the plasma membrane (0.5-1 min). Later (1-5 min) cGMP localization was diffuse in cytoplasm with perinuclear accentuation. Inactive insulin analogs did not elicit these changes.
- Tetrahymena pyriformis
- cyclic GMP
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)