Rapid development of glomerulosclerosis in diabetic Dahl salt-sensitive rats

A. Körner, G. Jaremko, A. C. Eklöf, A. Aperia

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Diabetic nehropathy tends to develop more readily in patients with a family history of hypertension and/or disturbances in sodium transport across the plasma membrane. This prompted us to study the renal effects of diabetes mellitus in a rat strain which is predisposed to develop salt-sensitive hypertension, the Dahl salt-sensitive rat. Diabetes is associated with several aberrations in the renal handling of sodium, such as elevation of tubular Na+, K+ATPase activity. This effect was more pronounced in Dahl salt-sensitive than in Dahl salt-resistant rats. Severe renal lesions, characteristic of the advanced phase of diabetic nephropathy are very rarely observed in rats with streptozotocin diabetes. However, 2 months after induction of diabetes, the Dahl salt-sensitive rats had morphological signs of advanced glomerular disease. The urinary albumin concentration was very high, but did not correlate with the blood pressure. Non-diabetic Dahl salt-sensitive rats as well as Dahl salt-resistant diabetic and non-diabetic rats had little or no signs of glomerular disease and consistently very low urinary albumin concentrations.

Original languageEnglish
Pages (from-to)367-373
Number of pages7
JournalDiabetologia
Volume40
Issue number4
DOIs
Publication statusPublished - 1997

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Inbred Dahl Rats
Diabetic Nephropathies
Salts
Kidney
Albumins
Sodium
Hypertension
Experimental Diabetes Mellitus
Diabetes Mellitus
Cell Membrane
Blood Pressure

Keywords

  • Dahl rats
  • diabetic nephropathy
  • salt sensitivity

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Rapid development of glomerulosclerosis in diabetic Dahl salt-sensitive rats. / Körner, A.; Jaremko, G.; Eklöf, A. C.; Aperia, A.

In: Diabetologia, Vol. 40, No. 4, 1997, p. 367-373.

Research output: Contribution to journalArticle

Körner, A. ; Jaremko, G. ; Eklöf, A. C. ; Aperia, A. / Rapid development of glomerulosclerosis in diabetic Dahl salt-sensitive rats. In: Diabetologia. 1997 ; Vol. 40, No. 4. pp. 367-373.
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