Rapid communication: Water disinfection by-products enhanced apoptotic activity in human lymphocytes

Gergely Rácz, László Sujbert, József Bocsi, B. Szende

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The apoptosis-inducing activity of concentrated sediments of disinfected and non-disinfected water samples from the waterworks in Budapest, Hungary, was investigated using cultures of human peripherial blood lymphocytes. Chlorine-treated water and untreated (raw) water sediments were concentrated with the use of Amberlite XAD-2 resin columns. The concentrates were dissolved in dimethyl sulfoxide and added to cultures of human peripherial blood lymphocytes. Apoptotic index was determined in lymphocytes after treatment with the raw or disinfected concentrates by flow cytomerty. Disinfected water concentrates of 100 μl/ml increased the apoptotic ratio of lymphocyte culture. The same amount of raw water concentrate also enhanced apoptosis. Both raw water and disinfected water contain substances that induced a significant rate of apoptosis in lymphocyte cultures.

Original languageEnglish
Pages (from-to)1315-1319
Number of pages5
JournalJournal of Toxicology and Environmental Health - Part A
Volume67
Issue number17
DOIs
Publication statusPublished - Sep 10 2004

Fingerprint

Lymphocytes
Disinfection
apoptosis
Human Activities
disinfection
Byproducts
Communication
communication
Water
Cell culture
blood
Cell death
water
sediment
Apoptosis
chlorine
resin
Sediments
Blood
Waterworks

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health
  • Pollution
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Rapid communication : Water disinfection by-products enhanced apoptotic activity in human lymphocytes. / Rácz, Gergely; Sujbert, László; Bocsi, József; Szende, B.

In: Journal of Toxicology and Environmental Health - Part A, Vol. 67, No. 17, 10.09.2004, p. 1315-1319.

Research output: Contribution to journalArticle

@article{07c20a6331b448a6ba8307c688260a05,
title = "Rapid communication: Water disinfection by-products enhanced apoptotic activity in human lymphocytes",
abstract = "The apoptosis-inducing activity of concentrated sediments of disinfected and non-disinfected water samples from the waterworks in Budapest, Hungary, was investigated using cultures of human peripherial blood lymphocytes. Chlorine-treated water and untreated (raw) water sediments were concentrated with the use of Amberlite XAD-2 resin columns. The concentrates were dissolved in dimethyl sulfoxide and added to cultures of human peripherial blood lymphocytes. Apoptotic index was determined in lymphocytes after treatment with the raw or disinfected concentrates by flow cytomerty. Disinfected water concentrates of 100 μl/ml increased the apoptotic ratio of lymphocyte culture. The same amount of raw water concentrate also enhanced apoptosis. Both raw water and disinfected water contain substances that induced a significant rate of apoptosis in lymphocyte cultures.",
author = "Gergely R{\'a}cz and L{\'a}szl{\'o} Sujbert and J{\'o}zsef Bocsi and B. Szende",
year = "2004",
month = "9",
day = "10",
doi = "10.1080/15287390490471415",
language = "English",
volume = "67",
pages = "1315--1319",
journal = "Journal of Toxicology and Environmental Health - Part A: Current Issues",
issn = "1528-7394",
publisher = "Taylor and Francis Ltd.",
number = "17",

}

TY - JOUR

T1 - Rapid communication

T2 - Water disinfection by-products enhanced apoptotic activity in human lymphocytes

AU - Rácz, Gergely

AU - Sujbert, László

AU - Bocsi, József

AU - Szende, B.

PY - 2004/9/10

Y1 - 2004/9/10

N2 - The apoptosis-inducing activity of concentrated sediments of disinfected and non-disinfected water samples from the waterworks in Budapest, Hungary, was investigated using cultures of human peripherial blood lymphocytes. Chlorine-treated water and untreated (raw) water sediments were concentrated with the use of Amberlite XAD-2 resin columns. The concentrates were dissolved in dimethyl sulfoxide and added to cultures of human peripherial blood lymphocytes. Apoptotic index was determined in lymphocytes after treatment with the raw or disinfected concentrates by flow cytomerty. Disinfected water concentrates of 100 μl/ml increased the apoptotic ratio of lymphocyte culture. The same amount of raw water concentrate also enhanced apoptosis. Both raw water and disinfected water contain substances that induced a significant rate of apoptosis in lymphocyte cultures.

AB - The apoptosis-inducing activity of concentrated sediments of disinfected and non-disinfected water samples from the waterworks in Budapest, Hungary, was investigated using cultures of human peripherial blood lymphocytes. Chlorine-treated water and untreated (raw) water sediments were concentrated with the use of Amberlite XAD-2 resin columns. The concentrates were dissolved in dimethyl sulfoxide and added to cultures of human peripherial blood lymphocytes. Apoptotic index was determined in lymphocytes after treatment with the raw or disinfected concentrates by flow cytomerty. Disinfected water concentrates of 100 μl/ml increased the apoptotic ratio of lymphocyte culture. The same amount of raw water concentrate also enhanced apoptosis. Both raw water and disinfected water contain substances that induced a significant rate of apoptosis in lymphocyte cultures.

UR - http://www.scopus.com/inward/record.url?scp=4043076527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4043076527&partnerID=8YFLogxK

U2 - 10.1080/15287390490471415

DO - 10.1080/15287390490471415

M3 - Article

C2 - 15371234

AN - SCOPUS:4043076527

VL - 67

SP - 1315

EP - 1319

JO - Journal of Toxicology and Environmental Health - Part A: Current Issues

JF - Journal of Toxicology and Environmental Health - Part A: Current Issues

SN - 1528-7394

IS - 17

ER -