Rapid alterations in cAMP accumulation in brain nuclei of rats following microinjections of vasoactive intestinal polypeptide (VIP) into the lateral ventricle

M. Palkóvits, G. Schmid, U. Bahner, K. Hempel, A. Heidland

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The in vivo effect of exogenous vasoactive intestinal polypeptide (VIP) on the accumulation of cAMP in 21 microdissected brain nuclei was investigated 3 and 7 min after intraventricular injections in rats. VIP elicited significant (up to 20-fold) increases in cAMP levels. This effect is region specific varying considerably among the brain regions investigated. VIP dramatically increased the cAMP content of the lateral septal nucleus, several hypothalamic nuclei, the habenula, the midbrain central gray and the locus coeruleus. Smaller increases were observed elsewhere including some VIP-rich brain areas such as the cerebral cortex and the hippocampus.

Original languageEnglish
Pages (from-to)351-355
Number of pages5
JournalNeuropeptides
Volume25
Issue number6
DOIs
Publication statusPublished - 1993

Fingerprint

Lateral Ventricles
Vasoactive Intestinal Peptide
Microinjections
Rats
Brain
Habenula
Intraventricular Injections
Septal Nuclei
Periaqueductal Gray
Locus Coeruleus
Cerebral Cortex
Hippocampus

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Rapid alterations in cAMP accumulation in brain nuclei of rats following microinjections of vasoactive intestinal polypeptide (VIP) into the lateral ventricle. / Palkóvits, M.; Schmid, G.; Bahner, U.; Hempel, K.; Heidland, A.

In: Neuropeptides, Vol. 25, No. 6, 1993, p. 351-355.

Research output: Contribution to journalArticle

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