Randomized evaluation of a novel, fixed-dose combination of perindopril 3.5mg/amlodipine 2.5mg as a first-step treatment in hypertension

Stéphane Laurent, Gianfranco Parati, Irina Chazova, Yuriy Sirenko, Andrejs Erglis, Aleksandras Laucevicius, C. Farsang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

OBJECTIVE:: To evaluate perindopril 3.5mg/amlodipine 2.5mg once daily, a novel fixed-dose combination adapted for first-step treatment in patients with hypertension. This fixed dose had to be equivalent to amlodipine 5mg in terms of blood pressure efficacy, but with an expected better tolerability profile. We selected two drugs with complementary modes of action, with doses chosen so that each drug would contribute similarly to the overall blood pressure-lowering effect METHODS:: An international, randomized, double-blind, placebo-controlled study with six equal parallel treatment arms and an 8-week randomized treatment period, whose design, clinical significance and non-inferiority criteria were in accordance with European guidelines. RESULTS:: In all, 1581 patients with mild-to-moderate uncomplicated hypertension (mean age 51.7 years) were randomized and 94.7% completed the study. The combination was statistically and clinically superior to placebo (between-group differences: SBP: -7.22mmHg, DBP: -4.12mmHg, P

Original languageEnglish
Pages (from-to)653-662
Number of pages10
JournalJournal of Hypertension
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 6 2015

Fingerprint

Hypertension
Placebos
Blood Pressure
Amlodipine
Pharmaceutical Preparations
Therapeutics
Guidelines
Viacoram
perindopril drug combination amlodipine

Keywords

  • amlodipine
  • antihypertensive agents
  • drug combinations
  • hypertension/drug therapy
  • perindopril

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Randomized evaluation of a novel, fixed-dose combination of perindopril 3.5mg/amlodipine 2.5mg as a first-step treatment in hypertension. / Laurent, Stéphane; Parati, Gianfranco; Chazova, Irina; Sirenko, Yuriy; Erglis, Andrejs; Laucevicius, Aleksandras; Farsang, C.

In: Journal of Hypertension, Vol. 33, No. 3, 06.03.2015, p. 653-662.

Research output: Contribution to journalArticle

Laurent, Stéphane ; Parati, Gianfranco ; Chazova, Irina ; Sirenko, Yuriy ; Erglis, Andrejs ; Laucevicius, Aleksandras ; Farsang, C. / Randomized evaluation of a novel, fixed-dose combination of perindopril 3.5mg/amlodipine 2.5mg as a first-step treatment in hypertension. In: Journal of Hypertension. 2015 ; Vol. 33, No. 3. pp. 653-662.
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