Randomised clinical trial: A 1-week, double-blind, placebo-controlled study of pancreatin 25 000 Ph. Eur. minimicrospheres (Creon 25000 MMS) for pancreatic exocrine insufficiency after pancreatic surgery, with a 1-year open-label extension

C. M. Seiler, J. Izbicki, L. Varga-Szabõ, L. Czakó, J. Fiõk, C. Sperti, M. M. Lerch, R. Pezzilli, G. Vasileva, A. Pap, M. Varga, H. Friess

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34 Citations (Scopus)

Abstract

Summary Background Pancreatic exocrine insufficiency (PEI) often occurs following pancreatic surgery. Aim To demonstrate the superior efficacy of pancreatin 25 000 minimicrospheres (Creon 25000 MMS; 9-15 capsules/day) over placebo in treating PEI after pancreatic resection. Methods A 1-week, double-blind, randomised, placebo-controlled, parallel-group, multicentre study with a 1-year, open-label extension (OLE). Subjects ≥18 years old with PEI after pancreatic resection, defined as baseline coefficient of fat absorption (CFA)

Original languageEnglish
Pages (from-to)691-702
Number of pages12
JournalAlimentary Pharmacology and Therapeutics
Volume37
Issue number7
DOIs
Publication statusPublished - Apr 2013

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Pancreatin
Exocrine Pancreatic Insufficiency
Randomized Controlled Trials
Placebos
Multicenter Studies
Capsules
Fats

ASJC Scopus subject areas

  • Pharmacology (medical)

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Randomised clinical trial : A 1-week, double-blind, placebo-controlled study of pancreatin 25 000 Ph. Eur. minimicrospheres (Creon 25000 MMS) for pancreatic exocrine insufficiency after pancreatic surgery, with a 1-year open-label extension. / Seiler, C. M.; Izbicki, J.; Varga-Szabõ, L.; Czakó, L.; Fiõk, J.; Sperti, C.; Lerch, M. M.; Pezzilli, R.; Vasileva, G.; Pap, A.; Varga, M.; Friess, H.

In: Alimentary Pharmacology and Therapeutics, Vol. 37, No. 7, 04.2013, p. 691-702.

Research output: Contribution to journalArticle

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