Random matrix analysis of localization properties of gene coexpression network

Sarika Jalan, Norbert Solymosi, Gábor Vattay, Baowen Li

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We analyze gene coexpression network under the random matrix theory framework. The nearest-neighbor spacing distribution of the adjacency matrix of this network follows Gaussian orthogonal statistics of random matrix theory (RMT). Spectral rigidity test follows random matrix prediction for a certain range and deviates afterwards. Eigenvector analysis of the network using inverse participation ratio suggests that the statistics of bulk of the eigenvalues of network is consistent with those of the real symmetric random matrix, whereas few eigenvalues are localized. Based on these IPR calculations, we can divide eigenvalues in three sets: (a) The nondegenerate part that follows RMT. (b) The nondegenerate part, at both ends and at intermediate eigenvalues, which deviates from RMT and expected to contain information about important nodes in the network. (c) The degenerate part with zero eigenvalue, which fluctuates around RMT-predicted value. We identify nodes corresponding to the dominant modes of the corresponding eigenvectors and analyze their structural properties.

Original languageEnglish
Article number046118
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume81
Issue number4
DOIs
Publication statusPublished - Apr 28 2010

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

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