Raman Spectroscopy for Process Analytical Technologies of Pharmaceutical Secondary Manufacturing

Brigitta Nagy, Attila Farkas, Enikő Borbás, Panna Vass, Zsombor Kristóf Nagy, G. Marosi

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

As the process analytical technology (PAT) mindset is progressively introduced and adopted by the pharmaceutical companies, there is an increasing demand for effective and versatile real-time analyzers to address the quality assurance challenges of drug manufacturing. In the last decades, Raman spectroscopy has emerged as one of the most promising tools for non-destructive and fast characterization of the pharmaceutical processes. This review summarizes the achieved results of the real-time application of Raman spectroscopy in the field of the secondary manufacturing of pharmaceutical solid dosage forms, covering the most common secondary process steps of a tablet production line. In addition, the feasibility of Raman spectroscopy for real-time control is critically reviewed, and challenges and possible approaches to moving from real-time monitoring to process analytically controlled technologies (PACT) are discussed.

Original languageEnglish
Article number1
JournalAAPS PharmSciTech
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • process analytical technology
  • process analytically controlled technology
  • Raman spectroscopy
  • secondary pharmaceutical manufacturing
  • spectroscopy-based control

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Pharmaceutical Science
  • Drug Discovery

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