Raman spectroscopic investigation of film thickness

T. Sovány, K. Nikowitz, G. Regdon, P. Kása, K. Pintye-Hódi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The determination of film thickness is of prime importance in the quality assurance of coated pharmaceutical preparations. The rapid measurement of this parameter is problematic for multi-particulate pellet systems. The aim of this study was to apply the Raman spectroscopic method for the determination of the thickness of polymer coating on pellets. The change of Raman intensity was compared with measured film thickness, which was calculated from the change of the geometric parameters of the pellets, measured with an image-analyzing system. The results revealed that despite some difficulties Raman spectroscopy is a suitable method for the fast and accurate determination of film thickness on multi-particulate systems.

Original languageEnglish
Pages (from-to)770-772
Number of pages3
JournalPolymer Testing
Volume28
Issue number7
DOIs
Publication statusPublished - Oct 2009

Fingerprint

Film thickness
Quality assurance
Drug products
Raman spectroscopy
Polymers
Coatings
Pharmaceutical Preparations

Keywords

  • Film thickness
  • Image analysis
  • Pellets
  • Raman spectroscopy

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics

Cite this

Raman spectroscopic investigation of film thickness. / Sovány, T.; Nikowitz, K.; Regdon, G.; Kása, P.; Pintye-Hódi, K.

In: Polymer Testing, Vol. 28, No. 7, 10.2009, p. 770-772.

Research output: Contribution to journalArticle

Sovány, T. ; Nikowitz, K. ; Regdon, G. ; Kása, P. ; Pintye-Hódi, K. / Raman spectroscopic investigation of film thickness. In: Polymer Testing. 2009 ; Vol. 28, No. 7. pp. 770-772.
@article{92a08ee861264dd79382fe98ce13ce4f,
title = "Raman spectroscopic investigation of film thickness",
abstract = "The determination of film thickness is of prime importance in the quality assurance of coated pharmaceutical preparations. The rapid measurement of this parameter is problematic for multi-particulate pellet systems. The aim of this study was to apply the Raman spectroscopic method for the determination of the thickness of polymer coating on pellets. The change of Raman intensity was compared with measured film thickness, which was calculated from the change of the geometric parameters of the pellets, measured with an image-analyzing system. The results revealed that despite some difficulties Raman spectroscopy is a suitable method for the fast and accurate determination of film thickness on multi-particulate systems.",
keywords = "Film thickness, Image analysis, Pellets, Raman spectroscopy",
author = "T. Sov{\'a}ny and K. Nikowitz and G. Regdon and P. K{\'a}sa and K. Pintye-H{\'o}di",
year = "2009",
month = "10",
doi = "10.1016/j.polymertesting.2009.05.001",
language = "English",
volume = "28",
pages = "770--772",
journal = "Polymer Testing",
issn = "0142-9418",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - Raman spectroscopic investigation of film thickness

AU - Sovány, T.

AU - Nikowitz, K.

AU - Regdon, G.

AU - Kása, P.

AU - Pintye-Hódi, K.

PY - 2009/10

Y1 - 2009/10

N2 - The determination of film thickness is of prime importance in the quality assurance of coated pharmaceutical preparations. The rapid measurement of this parameter is problematic for multi-particulate pellet systems. The aim of this study was to apply the Raman spectroscopic method for the determination of the thickness of polymer coating on pellets. The change of Raman intensity was compared with measured film thickness, which was calculated from the change of the geometric parameters of the pellets, measured with an image-analyzing system. The results revealed that despite some difficulties Raman spectroscopy is a suitable method for the fast and accurate determination of film thickness on multi-particulate systems.

AB - The determination of film thickness is of prime importance in the quality assurance of coated pharmaceutical preparations. The rapid measurement of this parameter is problematic for multi-particulate pellet systems. The aim of this study was to apply the Raman spectroscopic method for the determination of the thickness of polymer coating on pellets. The change of Raman intensity was compared with measured film thickness, which was calculated from the change of the geometric parameters of the pellets, measured with an image-analyzing system. The results revealed that despite some difficulties Raman spectroscopy is a suitable method for the fast and accurate determination of film thickness on multi-particulate systems.

KW - Film thickness

KW - Image analysis

KW - Pellets

KW - Raman spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=68549094230&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68549094230&partnerID=8YFLogxK

U2 - 10.1016/j.polymertesting.2009.05.001

DO - 10.1016/j.polymertesting.2009.05.001

M3 - Article

VL - 28

SP - 770

EP - 772

JO - Polymer Testing

JF - Polymer Testing

SN - 0142-9418

IS - 7

ER -