Raman microscopic evaluation of technology dependent structural differences in tablets containing imipramine model drug

Balázs Vajna, István Farkas, András Szabó, Zsolt Zsigmond, György Marosi

Research output: Contribution to journalArticle

50 Citations (Scopus)


Raman imaging method was used to characterize the effect of different manufacturing technologies on properties of the produced tablets, such as compound distribution, polymorphism, strength, and estimated active pharmaceutical ingredient (API) content. The obtained chemical maps were evaluated based on their visual appearance and on the statistical properties of the component scores obtained by direct classical least squares (DCLS) modelling. It is demonstrated that changes in the distribution of the API and excipients can be detected with chemical imaging and these differences are in close relationship with the applied granulation method and with the mechanical properties of the analyzed tablet. It is also shown that the chemical images used for characterizing the component distribution can also be processed for obtaining a cautious estimation to the mass fractions of the components.

Original languageEnglish
Pages (from-to)30-38
Number of pages9
JournalJournal of Pharmaceutical and Biomedical Analysis
Issue number1
Publication statusPublished - Jan 5 2010



  • Chemical imaging
  • Polymorphism
  • Raman spectroscopy
  • Tablet composition
  • Tablet manufacturing

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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