Raloxifene, an oestrogen-receptor modulator, prevents decreased constitutive nitric oxide and vasoconstriction in ovariectomized rats

Imre Pávó, F. László, E. Morschl, János Nemcsik, A. Berkó, David A. Cox, F. László

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Administration of graded doses of [Arg8]vasopressin (0.06-0.18 μg kg-1, i.v.) induced a dose-dependent increase in arterial blood pressure in the catecholamine-depleted (phentolamine; 10 mg kg-1, i.p.) intact and ovariectomized female rat, with the elevation of blood pressure more marked following ovariectomy. In addition, ovariectomy caused the down-regulation of aortic Ca2+-dependent constitutive nitric oxide synthase (assessed by the citrulline assay). The down-regulation of the Ca2+-dependent constitutive nitric oxide synthase and augmentation of vasopressin-induced blood pressure responses were prevented by the therapy (1 month, p.o.) with the selective oestrogen receptor modulator, raloxifene (0.3-1.0 mg kg-1 day-1), or with 17β-oestradiol (0.3 mg kg-1 day-1) in ovariectomized rats. Thus, oestrogen deficiency down-regulates vascular constitutive nitric oxide synthase, which appears to be involved in the increased sensitivity of the vasculature to vasopressin, since both effects can be reversed by the exogenous administration of the natural oestrogen 17β-oestradiol or the selective oestrogen-receptor modulator raloxifene.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalEuropean Journal of Pharmacology
Volume410
Issue number1
DOIs
Publication statusPublished - Dec 20 2000

Fingerprint

Estrogen Receptor Modulators
Vasoconstriction
Vasopressins
Nitric Oxide Synthase
Selective Estrogen Receptor Modulators
Nitric Oxide
Down-Regulation
Ovariectomy
Estradiol
Estrogens
Blood Pressure
Citrulline
Phentolamine
Catecholamines
Blood Vessels
Arterial Pressure
Raloxifene Hydrochloride
Therapeutics

Keywords

  • Blood pressure
  • Enzyme regulation
  • Nitric oxide (NO)
  • Oestrogen
  • Oestrogen receptor modulator
  • Vasopressin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Raloxifene, an oestrogen-receptor modulator, prevents decreased constitutive nitric oxide and vasoconstriction in ovariectomized rats. / Pávó, Imre; László, F.; Morschl, E.; Nemcsik, János; Berkó, A.; Cox, David A.; László, F.

In: European Journal of Pharmacology, Vol. 410, No. 1, 20.12.2000, p. 101-104.

Research output: Contribution to journalArticle

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