Radiodetoxified lipopolysaccharide fails to activate the hypophyseal-pituitary-adrenal axis in the rat

István Barna, L. Bertók, J. I. Koenig, G. B. Makara

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Lipopolysaccharide (LPS) is known to raise the concentration of the circulating stress hormones such as ACTH, corticosterone and β-endorphin. This effect of endotoxin is mediated by different immune system-released hormone-like factors (e.g. interleukins, tumor necrosis factor etc.). Gamma-ray irradiation of LPS alters its biological properties and results in a radiodetoxified LPS preparation with numerous beneficial effects and decreased toxicity. In this study we compared the neuroendocrine effects of a commercial LPS and our native and radiode-toxified LPS preparations in rats. Plasma ACTH, corticosterone and β-endorphin levels were measured by specific radioimmunoassays 120 min after intraperitoneal LPS administration. Control animals were injected with saline. Results show a dramatic increase in all hormones after administration of commercial and our native LPS preparation. Hormone levels in saline-injected controls and radiodetoxified LPS-treated rats did not rise significantly. These results suggest that radio-detoxification disintegrated that part of the LPS molecule complex which is responsible for toxicity including an enhanced production of cytokines, which trigger the hypothalamo-pituitary-adrenal axis.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalNeuroImmunoModulation
Volume8
Issue number3
DOIs
Publication statusPublished - Dec 1 2000

ASJC Scopus subject areas

  • Immunology
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems

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