Radioassay of soluble immune complexes using their uptake by macrophage Fc receptors

M. Kavai, K. Dankó, E. Kalmar, I. Francia, G. Szegedi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Sera from patients were tested for the presence of soluble immune complexes (IC) by a method based on the observation that IC inhibit uptake of aggregated IgG by the Fc receptors of macrophages. From the saturation curve of macrophages with 125I-labelled aggregates the optimal inhibitory effect of a measured amount of IC was determined. This radioassay is highly sensitive, being capable of detecting 20 ng of IC, is reproducible and covers a wide range of measurement (20-2000 ng).

Original languageEnglish
Pages (from-to)617-621
Number of pages5
JournalImmunology
Volume32
Issue number5
Publication statusPublished - 1977

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Fc Receptors
Antigen-Antibody Complex
Macrophages
IgG Receptors
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Radioassay of soluble immune complexes using their uptake by macrophage Fc receptors. / Kavai, M.; Dankó, K.; Kalmar, E.; Francia, I.; Szegedi, G.

In: Immunology, Vol. 32, No. 5, 1977, p. 617-621.

Research output: Contribution to journalArticle

Kavai, M. ; Dankó, K. ; Kalmar, E. ; Francia, I. ; Szegedi, G. / Radioassay of soluble immune complexes using their uptake by macrophage Fc receptors. In: Immunology. 1977 ; Vol. 32, No. 5. pp. 617-621.
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