Radical serotype rearrangement of carried pneumococci in the first 3 years after intensive vaccination started in Hungary

Adrienn Tóthpál, Szilvia Kardos, Krisztina Laub, K. Nagy, Tamás Tirczka, Mark van der Linden, Orsolya Dobay

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Streptococcus pneumoniae is responsible for a significant amount of morbidity and mortality worldwide. Healthy carriers, mainly young children, are the most important sources of infections. In the current study, we aimed to determine the changes that have occurred since the introduction of PCV-7 in Hungary. Nasal specimens were collected from 1,022 healthy children aged 3–6 years attending day-care centres. After thorough identification, pneumococcal isolates were serotyped, and their antibiotic sensitivity was determined. The carriage rate was found to be 34.9 %. A huge serotype rearrangement was detected compared to earlier results, with the previously leading serotype 14 having completely disappeared. Serotypes 11A, 35F, 19A, 6B, 15B, 3 and 38 were most prevalent, and 29 different types were identified in total. The PCV-7 types were responsible for 16.5 % of all serotypes, and 36.0 % are not covered by any pneumococcal vaccines. The isolates were sensitive to most tested antibiotics, except erythromycin (resistance was 21.6 %). Only one penicillin-resistant strain was found. The newly and rapidly emerging non-vaccine serotypes are much more sensitive, except serotype 19A. Conclusion: Due to PCV vaccination, a complete serotype arrangement occurred also in Hungary. The old “paediatric” serotypes were replaced by serotypes 11A, 35F, 19A, 6B, 15B, 3 and 38.

Original languageEnglish
Pages (from-to)373-381
Number of pages9
JournalEuropean Journal of Pediatrics
Volume174
Issue number3
DOIs
Publication statusPublished - 2015

Fingerprint

Hungary
Streptococcus pneumoniae
Vaccination
Anti-Bacterial Agents
Serogroup
Pneumococcal Vaccines
Erythromycin
Nose
Penicillins
Pediatrics
Morbidity
Mortality

Keywords

  • Carriage
  • Day-care centres
  • PCV-7 vaccination
  • Pneumococcus
  • Serotype changing

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Radical serotype rearrangement of carried pneumococci in the first 3 years after intensive vaccination started in Hungary. / Tóthpál, Adrienn; Kardos, Szilvia; Laub, Krisztina; Nagy, K.; Tirczka, Tamás; van der Linden, Mark; Dobay, Orsolya.

In: European Journal of Pediatrics, Vol. 174, No. 3, 2015, p. 373-381.

Research output: Contribution to journalArticle

Tóthpál, Adrienn ; Kardos, Szilvia ; Laub, Krisztina ; Nagy, K. ; Tirczka, Tamás ; van der Linden, Mark ; Dobay, Orsolya. / Radical serotype rearrangement of carried pneumococci in the first 3 years after intensive vaccination started in Hungary. In: European Journal of Pediatrics. 2015 ; Vol. 174, No. 3. pp. 373-381.
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