Radical-mediated bromination of carbohydrate derivatives: Searching for alternative reaction conditions without carbon tetrachloride

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Abstract

KBrO3-Na2S2O4 in CH2Cl2-H2O or PhCF3-H2O biphasic solvent systems was applied to the bromination of several monosaccharide derivatives having capto-datively substituted reaction centres. With less reactive compounds neat PhCF3 was shown to be a suitable substitute of the health and environmentally hazardous carbon tetrachloride.

Original languageEnglish
Pages (from-to)8849-8852
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number49
DOIs
Publication statusPublished - Dec 2 2002

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Keywords

  • Carbohydrates
  • Halogenation
  • Radicals and radical reactions
  • Substitution

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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