Radiation myelopathy with partial functional recovery

PET evidence of long-term increased metabolic activity of the spinal cord

O. Ésik, M. Emri, Márta Csornai, M. Kásler, Mária Godény, L. Trón

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Postoperative telecobalt irradiation was performed with a biologically effective extrapolated response dose of 165 Gy2 delivered to the spinal cord of a papillary thyroid cancer patient. Incomplete cervical transection developed, followed by a gradual functional improvement, which is still continuing 8 years after radiotherapy. Between the 6th and 8th years of the clinical course, positron emission tomography investigations demonstrated an increased 18F-deoxyglucose accumulation and 15O-butanol perfusion, but negligible 11C-methionine uptake in the irradiated spinal cord segment. We suggest that the increased metabolism and perfusion, and the lack of detectable protein synthesis may be related to the increased energy demands of action potential conduction, due to the higher than normal density of sodium channels along demyelinated axons displaying restored conduction.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalJournal of the Neurological Sciences
Volume163
Issue number1
DOIs
Publication statusPublished - Feb 1 1999

Fingerprint

Spinal Cord Diseases
Spinal Cord
Perfusion
Radiation
Butanols
Sodium Channels
Deoxyglucose
Methionine
Positron-Emission Tomography
Action Potentials
Axons
Radiotherapy
Proteins
Papillary Thyroid cancer

Keywords

  • C-methionine
  • F-deoxyglucose; O-butanol
  • Functional recovery of conduction
  • Positron emission tomography
  • Radiation myelopathy
  • Sodium channels

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

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abstract = "Postoperative telecobalt irradiation was performed with a biologically effective extrapolated response dose of 165 Gy2 delivered to the spinal cord of a papillary thyroid cancer patient. Incomplete cervical transection developed, followed by a gradual functional improvement, which is still continuing 8 years after radiotherapy. Between the 6th and 8th years of the clinical course, positron emission tomography investigations demonstrated an increased 18F-deoxyglucose accumulation and 15O-butanol perfusion, but negligible 11C-methionine uptake in the irradiated spinal cord segment. We suggest that the increased metabolism and perfusion, and the lack of detectable protein synthesis may be related to the increased energy demands of action potential conduction, due to the higher than normal density of sodium channels along demyelinated axons displaying restored conduction.",
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T1 - Radiation myelopathy with partial functional recovery

T2 - PET evidence of long-term increased metabolic activity of the spinal cord

AU - Ésik, O.

AU - Emri, M.

AU - Csornai, Márta

AU - Kásler, M.

AU - Godény, Mária

AU - Trón, L.

PY - 1999/2/1

Y1 - 1999/2/1

N2 - Postoperative telecobalt irradiation was performed with a biologically effective extrapolated response dose of 165 Gy2 delivered to the spinal cord of a papillary thyroid cancer patient. Incomplete cervical transection developed, followed by a gradual functional improvement, which is still continuing 8 years after radiotherapy. Between the 6th and 8th years of the clinical course, positron emission tomography investigations demonstrated an increased 18F-deoxyglucose accumulation and 15O-butanol perfusion, but negligible 11C-methionine uptake in the irradiated spinal cord segment. We suggest that the increased metabolism and perfusion, and the lack of detectable protein synthesis may be related to the increased energy demands of action potential conduction, due to the higher than normal density of sodium channels along demyelinated axons displaying restored conduction.

AB - Postoperative telecobalt irradiation was performed with a biologically effective extrapolated response dose of 165 Gy2 delivered to the spinal cord of a papillary thyroid cancer patient. Incomplete cervical transection developed, followed by a gradual functional improvement, which is still continuing 8 years after radiotherapy. Between the 6th and 8th years of the clinical course, positron emission tomography investigations demonstrated an increased 18F-deoxyglucose accumulation and 15O-butanol perfusion, but negligible 11C-methionine uptake in the irradiated spinal cord segment. We suggest that the increased metabolism and perfusion, and the lack of detectable protein synthesis may be related to the increased energy demands of action potential conduction, due to the higher than normal density of sodium channels along demyelinated axons displaying restored conduction.

KW - C-methionine

KW - F-deoxyglucose; O-butanol

KW - Functional recovery of conduction

KW - Positron emission tomography

KW - Radiation myelopathy

KW - Sodium channels

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