Radiation-induced enterocolitis: Basic and applied science

Sandor Szabo, Zsuzsa Sandor, Aron Vincze, Zoltan Gombos, Ahmed Mohiuddin, Thavinsakdi Viravathana

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We adapted and introduced in our laboratory a simplified animal model of radiation-induced enterocolitis. After a shielding of the parenchymatous organs, our dose-response studies revealed that 20 Gy x-ray radiation resulted in about 20% mortality and reproducible lesions in the terminal ileum and proximal colon. These changes are optimal for pharmacologic studies since they may be decreased or aggravated by drugs. Sucralfate dose- dependently decreased the clinical signs of enterocolitis (e.g., lethargy, diarrhea) as well as the number and area of ileal and colonic erosions and ulcers. The wet weight of the ileum and colon were also decreased by sucralfate. bFGF at the small doses used exerted a beneficial effect only on a few of the parameters of enterocolitis. Thus sucralfate, and maybe bFGF, might decrease the severity and accelerate the healing of radiation-induced enterocolitis.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalEuropean Journal of Surgery, Supplement
Volume164
Issue number582
Publication statusPublished - Jan 1 1998

Keywords

  • Abdominal radiation
  • Animal models
  • Enterocolitis
  • Sucralfate
  • bFGF

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Szabo, S., Sandor, Z., Vincze, A., Gombos, Z., Mohiuddin, A., & Viravathana, T. (1998). Radiation-induced enterocolitis: Basic and applied science. European Journal of Surgery, Supplement, 164(582), 85-89.