Radiation induced degradation of pharmaceutical residues in water: Chloramphenicol

Tamás Csay, Gergely Rácz, Erzsébet Takács, László Wojnárovits

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The γ-radiolytic degradation of chloramphenicol (CPL) was investigated in 0.1-1mmoldm-3 aqueous solutions at various radiation conditions. The destruction of CPL was monitored by UV-vis spectrophotometric method through the decrease in the intensity of the absorbance band at 276nm. LC-MS/MS was used to identify the degradation products. Results indicate that OH can add onto the CPL aromatic ring or can abstract H-atom from the side chain. The reductive dechlorination of CPL was also studied based on the reaction of eaq- with CPL. In 0.1mmoldm-3 solution above 2.5kGy dose complete CPL degradation was achieved. In the presence of dissolved oxygen at relatively low dose, various oxidation products were observed. In the presence of tertiary butanol radical scavenger tertiary butanol group containing products were also detected. The toxicity increased as a function of dose to 1.0kGy. At doses higher than 1.0kGy the toxicity decreased continuously due to further degradation. It was also demonstrated that the O2-•/HO2 pair has low reactivity in CPL solution.

Original languageEnglish
Pages (from-to)1489-1494
Number of pages6
JournalRadiation Physics and Chemistry
Volume81
Issue number9
DOIs
Publication statusPublished - Sep 1 2012

Keywords

  • Chemical oxygen demand
  • Chloramphenicol
  • Degradation
  • Ionizing radiation
  • Toxicity

ASJC Scopus subject areas

  • Radiation

Fingerprint Dive into the research topics of 'Radiation induced degradation of pharmaceutical residues in water: Chloramphenicol'. Together they form a unique fingerprint.

  • Cite this