Radiation induced degradation of ketoprofen in dilute aqueous solution

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The intermediates and final products of ketoprofen degradation were investigated in 0.4mmoldm-3 solution by pulse radiolysis and gamma radiolysis. For observation of final products UV-vis spectrophotometry and HPLC separation with diode array detection were used, and for identification MS was used. The reactions of OH lead to hydroxycyclohexadienyl type radical intermediates, in their further reactions hydroxylated derivatives of ketoprofen form as final products. The hydrated electron is scavenged by the carbonyl oxygen and the electron adduct protonates to ketyl radical OH is more effective in decomposing ketoprofen than hydrated electron. Chemical oxygen demand and total organic carbon content measurements on irradiated aerated solutions showed that using irradiation technology ketoprofen can be mineralised. The initial toxicity of the solution monitored by the Daphnia magna test steadily decreases with irradiation. Using 5kGy dose no toxicity of the solution was detected with this test.

Original languageEnglish
Pages (from-to)1479-1483
Number of pages5
JournalRadiation Physics and Chemistry
Volume81
Issue number9
DOIs
Publication statusPublished - Sep 2012

Fingerprint

degradation
aqueous solutions
radiation
radiolysis
toxicity
products
irradiation
electrons
oxygen
spectrophotometry
adducts
diodes
dosage
carbon
pulses

Keywords

  • Advanced oxidation processes
  • Hydrated electron
  • Hydroxyl radical
  • Ketoprofen
  • Radiolysis

ASJC Scopus subject areas

  • Radiation

Cite this

Radiation induced degradation of ketoprofen in dilute aqueous solution. / Illés, E.; Takács, E.; Dombi, A.; Gajda-Schrantz, K.; Gonter, Katalin; Wojnárovits, L.

In: Radiation Physics and Chemistry, Vol. 81, No. 9, 09.2012, p. 1479-1483.

Research output: Contribution to journalArticle

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AU - Illés, E.

AU - Takács, E.

AU - Dombi, A.

AU - Gajda-Schrantz, K.

AU - Gonter, Katalin

AU - Wojnárovits, L.

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N2 - The intermediates and final products of ketoprofen degradation were investigated in 0.4mmoldm-3 solution by pulse radiolysis and gamma radiolysis. For observation of final products UV-vis spectrophotometry and HPLC separation with diode array detection were used, and for identification MS was used. The reactions of •OH lead to hydroxycyclohexadienyl type radical intermediates, in their further reactions hydroxylated derivatives of ketoprofen form as final products. The hydrated electron is scavenged by the carbonyl oxygen and the electron adduct protonates to ketyl radical •OH is more effective in decomposing ketoprofen than hydrated electron. Chemical oxygen demand and total organic carbon content measurements on irradiated aerated solutions showed that using irradiation technology ketoprofen can be mineralised. The initial toxicity of the solution monitored by the Daphnia magna test steadily decreases with irradiation. Using 5kGy dose no toxicity of the solution was detected with this test.

AB - The intermediates and final products of ketoprofen degradation were investigated in 0.4mmoldm-3 solution by pulse radiolysis and gamma radiolysis. For observation of final products UV-vis spectrophotometry and HPLC separation with diode array detection were used, and for identification MS was used. The reactions of •OH lead to hydroxycyclohexadienyl type radical intermediates, in their further reactions hydroxylated derivatives of ketoprofen form as final products. The hydrated electron is scavenged by the carbonyl oxygen and the electron adduct protonates to ketyl radical •OH is more effective in decomposing ketoprofen than hydrated electron. Chemical oxygen demand and total organic carbon content measurements on irradiated aerated solutions showed that using irradiation technology ketoprofen can be mineralised. The initial toxicity of the solution monitored by the Daphnia magna test steadily decreases with irradiation. Using 5kGy dose no toxicity of the solution was detected with this test.

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