Radiation-induced coronary artery disease in Hodgkin's disease

Zsófia Miltényi, Katalin Keresztes, Ildikó Garai, I. Édes, Zoltán Galajda, L. Tóth, A. Illés

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose Secondary malignant tumours and cardiovascular complications are of great importance among the late complications after treatment for Hodgkin's disease (HD) because they may significantly reduce the patients' life expectancy. We report on coronary artery disease (CAD) after treatment for HD. Methods and Materials We present the case of two female patients with HD who received mediastinal irradiation after which complete remission was achieved. In 12 and 19 years after the onset of the disease, control examinations revealed ischaemic heart disease, which was confirmed by coronary arteriography and solved by stent implantation in one of the patients and bypass surgery in the other one. Conclusions Ischaemic heart disease was due to early CAD, which was associated with mediastinal irradiation accompanied by hypothyroidism, hyperlipidaemia and, possibly, early menopause, all posing an increased risk for the cardiologic disease. Our cases may serve as a warning example to carefully plan the management (low dose, involved field irradiation) of newly diagnosed patients as well as the cardiologic follow-up of patients with HD.

Original languageEnglish
Pages (from-to)38-43
Number of pages6
JournalCardiovascular Radiation Medicine
Volume5
Issue number1
DOIs
Publication statusPublished - Jan 2004

Fingerprint

Hodgkin Disease
Coronary Artery Disease
Radiation
Myocardial Ischemia
Menopause
Life Expectancy
Hypothyroidism
Hyperlipidemias
Stents
Angiography
Therapeutics
Neoplasms

Keywords

  • Coronary artery disease
  • Hodgkin's disease
  • Late complication
  • Radiotherapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Radiation-induced coronary artery disease in Hodgkin's disease. / Miltényi, Zsófia; Keresztes, Katalin; Garai, Ildikó; Édes, I.; Galajda, Zoltán; Tóth, L.; Illés, A.

In: Cardiovascular Radiation Medicine, Vol. 5, No. 1, 01.2004, p. 38-43.

Research output: Contribution to journalArticle

Miltényi, Zsófia ; Keresztes, Katalin ; Garai, Ildikó ; Édes, I. ; Galajda, Zoltán ; Tóth, L. ; Illés, A. / Radiation-induced coronary artery disease in Hodgkin's disease. In: Cardiovascular Radiation Medicine. 2004 ; Vol. 5, No. 1. pp. 38-43.
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