Racial Differences in Survival of Incident Home Hemodialysis and Kidney Transplant Patients

M. Molnár, Vanessa Ravel, Elani Streja, Csaba P. Kovesdy, Rajnish Mehrotra, Kamyar Kalantar-Zadeh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND: Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. METHODS: Comparing patients who started HHD with those who received kidney transplantation in the United States between 2007 and 2011, we created a 1:1 propensity score–matched cohort of 4000 patients and examined the association between treatment modality and all-cause mortality using Cox proportional hazard models. RESULTS: The mean ± SD age of the propensity score–matched HHD and KTx patients at baseline were 54 ± 15 years and 54 ± 14 years, 65% were men (both groups), 70% and 72% of patients were whites, and 19% were African American (both groups), respectively. Over 5 years of follow-up, HHD patients had 4 times higher mortality risk compared with KTx recipients in the entire patient population (hazard ratio [HR], 4.06; 95% confidence interval [95% CI], 3.27-5.04); total event number, 411), and similar difference was found across each race stratum. However, during the first year of therapy, although the white HHD patients had higher mortality risk (HR, 4.21; 95% CI, 3.10-5.73; total event number, 332) compared with their KTx counterparts, there was no significant difference in mortality risk between African American HHD and KTx patients (HR, 1.62; 95% CI, 0.77-3.39; total event number, 55). This result was consistent across different types of kidney donors. CONCLUSIONS: The HHD patients appear to have 4 times higher mortality compared with KTx recipients regardless of the type of kidney donor. Further studies are needed to understand the reasons underlying racial differenes during the first year of therapy.

Original languageEnglish
JournalTransplantation
DOIs
Publication statusAccepted/In press - Nov 19 2015

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Home Hemodialysis
Transplants
Kidney
Survival
Mortality
Confidence Intervals
African Americans
Tissue Donors
Proportional Hazards Models
Kidney Transplantation
Renal Dialysis
Dialysis

ASJC Scopus subject areas

  • Transplantation

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Racial Differences in Survival of Incident Home Hemodialysis and Kidney Transplant Patients. / Molnár, M.; Ravel, Vanessa; Streja, Elani; Kovesdy, Csaba P.; Mehrotra, Rajnish; Kalantar-Zadeh, Kamyar.

In: Transplantation, 19.11.2015.

Research output: Contribution to journalArticle

Molnár, M. ; Ravel, Vanessa ; Streja, Elani ; Kovesdy, Csaba P. ; Mehrotra, Rajnish ; Kalantar-Zadeh, Kamyar. / Racial Differences in Survival of Incident Home Hemodialysis and Kidney Transplant Patients. In: Transplantation. 2015.
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abstract = "BACKGROUND: Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. METHODS: Comparing patients who started HHD with those who received kidney transplantation in the United States between 2007 and 2011, we created a 1:1 propensity score–matched cohort of 4000 patients and examined the association between treatment modality and all-cause mortality using Cox proportional hazard models. RESULTS: The mean ± SD age of the propensity score–matched HHD and KTx patients at baseline were 54 ± 15 years and 54 ± 14 years, 65{\%} were men (both groups), 70{\%} and 72{\%} of patients were whites, and 19{\%} were African American (both groups), respectively. Over 5 years of follow-up, HHD patients had 4 times higher mortality risk compared with KTx recipients in the entire patient population (hazard ratio [HR], 4.06; 95{\%} confidence interval [95{\%} CI], 3.27-5.04); total event number, 411), and similar difference was found across each race stratum. However, during the first year of therapy, although the white HHD patients had higher mortality risk (HR, 4.21; 95{\%} CI, 3.10-5.73; total event number, 332) compared with their KTx counterparts, there was no significant difference in mortality risk between African American HHD and KTx patients (HR, 1.62; 95{\%} CI, 0.77-3.39; total event number, 55). This result was consistent across different types of kidney donors. CONCLUSIONS: The HHD patients appear to have 4 times higher mortality compared with KTx recipients regardless of the type of kidney donor. Further studies are needed to understand the reasons underlying racial differenes during the first year of therapy.",
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N2 - BACKGROUND: Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. METHODS: Comparing patients who started HHD with those who received kidney transplantation in the United States between 2007 and 2011, we created a 1:1 propensity score–matched cohort of 4000 patients and examined the association between treatment modality and all-cause mortality using Cox proportional hazard models. RESULTS: The mean ± SD age of the propensity score–matched HHD and KTx patients at baseline were 54 ± 15 years and 54 ± 14 years, 65% were men (both groups), 70% and 72% of patients were whites, and 19% were African American (both groups), respectively. Over 5 years of follow-up, HHD patients had 4 times higher mortality risk compared with KTx recipients in the entire patient population (hazard ratio [HR], 4.06; 95% confidence interval [95% CI], 3.27-5.04); total event number, 411), and similar difference was found across each race stratum. However, during the first year of therapy, although the white HHD patients had higher mortality risk (HR, 4.21; 95% CI, 3.10-5.73; total event number, 332) compared with their KTx counterparts, there was no significant difference in mortality risk between African American HHD and KTx patients (HR, 1.62; 95% CI, 0.77-3.39; total event number, 55). This result was consistent across different types of kidney donors. CONCLUSIONS: The HHD patients appear to have 4 times higher mortality compared with KTx recipients regardless of the type of kidney donor. Further studies are needed to understand the reasons underlying racial differenes during the first year of therapy.

AB - BACKGROUND: Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. METHODS: Comparing patients who started HHD with those who received kidney transplantation in the United States between 2007 and 2011, we created a 1:1 propensity score–matched cohort of 4000 patients and examined the association between treatment modality and all-cause mortality using Cox proportional hazard models. RESULTS: The mean ± SD age of the propensity score–matched HHD and KTx patients at baseline were 54 ± 15 years and 54 ± 14 years, 65% were men (both groups), 70% and 72% of patients were whites, and 19% were African American (both groups), respectively. Over 5 years of follow-up, HHD patients had 4 times higher mortality risk compared with KTx recipients in the entire patient population (hazard ratio [HR], 4.06; 95% confidence interval [95% CI], 3.27-5.04); total event number, 411), and similar difference was found across each race stratum. However, during the first year of therapy, although the white HHD patients had higher mortality risk (HR, 4.21; 95% CI, 3.10-5.73; total event number, 332) compared with their KTx counterparts, there was no significant difference in mortality risk between African American HHD and KTx patients (HR, 1.62; 95% CI, 0.77-3.39; total event number, 55). This result was consistent across different types of kidney donors. CONCLUSIONS: The HHD patients appear to have 4 times higher mortality compared with KTx recipients regardless of the type of kidney donor. Further studies are needed to understand the reasons underlying racial differenes during the first year of therapy.

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