Racemic compound formation-conglomerate formation: Part 4. Optical resolution and determination of the melting phase diagrams of 2′,6′-pipecoloxylidide and four 1-alkyl-2′,6′-pipecoloxylidides

Katalin Nemák, Mária Ács, D. Kozma, E. Fogassy

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The phenomena of conglomerate formation-racemic compound formation were investigated in a series of five (N-alkyl)-2′,6′-pipecoloxylidides. The optically active enantiomers were prepared by optical resolution of the racemates using 2R,3R-tartaric acid and 0,0′-dibenzoyl-2R,3R-tartaric acid as resolving agent. By DSC measurement of the racemates and the enantiomer the binary phase diagrams were determined. Among the four racemic molecular compounds the N-methyl derivative is the more stable. By increasing the length of the alkyl chain the stability of the racemic compound decreased, and in case of the longest -butyl- chain conglomerate formation was observed.

Original languageEnglish
Pages (from-to)691-696
Number of pages6
JournalJournal of Thermal Analysis
Volume48
Issue number3
Publication statusPublished - Mar 1997

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Enantiomers
Phase diagrams
Melting
enantiomers
phase diagrams
melting
Acids
acids
Derivatives
tartaric acid

Keywords

  • Conglomerate
  • DSC
  • Melting phase diagram
  • Recemic compound

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)
  • Physical and Theoretical Chemistry
  • Condensed Matter Physics
  • Engineering(all)

Cite this

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abstract = "The phenomena of conglomerate formation-racemic compound formation were investigated in a series of five (N-alkyl)-2′,6′-pipecoloxylidides. The optically active enantiomers were prepared by optical resolution of the racemates using 2R,3R-tartaric acid and 0,0′-dibenzoyl-2R,3R-tartaric acid as resolving agent. By DSC measurement of the racemates and the enantiomer the binary phase diagrams were determined. Among the four racemic molecular compounds the N-methyl derivative is the more stable. By increasing the length of the alkyl chain the stability of the racemic compound decreased, and in case of the longest -butyl- chain conglomerate formation was observed.",
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T2 - Part 4. Optical resolution and determination of the melting phase diagrams of 2′,6′-pipecoloxylidide and four 1-alkyl-2′,6′-pipecoloxylidides

AU - Nemák, Katalin

AU - Ács, Mária

AU - Kozma, D.

AU - Fogassy, E.

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AB - The phenomena of conglomerate formation-racemic compound formation were investigated in a series of five (N-alkyl)-2′,6′-pipecoloxylidides. The optically active enantiomers were prepared by optical resolution of the racemates using 2R,3R-tartaric acid and 0,0′-dibenzoyl-2R,3R-tartaric acid as resolving agent. By DSC measurement of the racemates and the enantiomer the binary phase diagrams were determined. Among the four racemic molecular compounds the N-methyl derivative is the more stable. By increasing the length of the alkyl chain the stability of the racemic compound decreased, and in case of the longest -butyl- chain conglomerate formation was observed.

KW - Conglomerate

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KW - Recemic compound

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