Race, Serum Potassium, and Associations With ESRD and Mortality

Yan Chen, Yingying Sang, Shoshana H. Ballew, Adrienne Tin, Alex R. Chang, Kunihiro Matsushita, Josef Coresh, Kamyar Kalantar-Zadeh, M. Molnár, Morgan E. Grams

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Abstract

Background Recent studies suggest that potassium levels may differ by race. The basis for these differences and whether associations between potassium levels and adverse outcomes differ by race are unknown. Study Design Observational study. Setting & Participants Associations between race and potassium level and the interaction of race and potassium level with outcomes were investigated in the Racial and Cardiovascular Risk Anomalies in Chronic Kidney Disease (RCAV) Study, a cohort of US veterans (N = 2,662,462). Associations between African ancestry and potassium level were investigated in African Americans in the Atherosclerosis Risk in Communities (ARIC) Study (N = 3,450). Predictors Race (African American vs non–African American and percent African ancestry) for cross-sectional analysis; serum potassium level for longitudinal analysis. Outcomes Potassium level for cross-sectional analysis; mortality and end-stage renal disease for longitudinal analysis. Results The RCAV cohort was 18% African American (N = 470,985). Potassium levels on average were 0.162 mmol/L lower in African Americans compared with non–African Americans, with differences persisting after adjustment for demographics, comorbid conditions, and potassium-altering medication use. In the ARIC Study, higher African ancestry was related to lower potassium levels (−0.027 mmol/L per each 10% African ancestry). In both race groups, higher and lower potassium levels were associated with mortality. Compared to potassium level of 4.2 mmol/L, mortality risk associated with lower potassium levels was lower in African Americans versus non–African Americans, whereas mortality risk associated with higher levels was slightly greater. Risk relationships between potassium and end-stage renal disease were weaker, with no difference by race. Limitations No data for potassium intake. Conclusions African Americans had slightly lower serum potassium levels than non–African Americans. Consistent associations between potassium levels and percent African ancestry may suggest a genetic component to these differences. Higher and lower serum potassium levels were associated with mortality in both racial groups.

Original languageEnglish
Pages (from-to)244-251
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume70
Issue number2
DOIs
Publication statusPublished - Aug 1 2017

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Keywords

  • African American
  • African ancestry
  • end-stage renal disease (ESRD)
  • genetic risk factor
  • hyperkalemia
  • hypokalemia
  • kidney disease
  • mortality
  • Race
  • racial differences
  • serum potassium

ASJC Scopus subject areas

  • Nephrology

Cite this

Chen, Y., Sang, Y., Ballew, S. H., Tin, A., Chang, A. R., Matsushita, K., Coresh, J., Kalantar-Zadeh, K., Molnár, M., & Grams, M. E. (2017). Race, Serum Potassium, and Associations With ESRD and Mortality. American Journal of Kidney Diseases, 70(2), 244-251. https://doi.org/10.1053/j.ajkd.2017.01.044