Quantitative ultrastructural study of afferent and efferent arterioles in IgA glomerulonephritis and benign nephrosclerosis

Zsolt Rázga, B. Iványi, Nina Zidar, Dusan Ferluga, S. Sonkodi, Jenö Ormos

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Arteriolosclerosis frequently occurs in IgA nephritis (IgAN), and it is the hallmark of benign nephrosclerosis (BNS). The quantitative ultrastructure of juxta-glomerular arterioles is not known in these disorders. We examined afferent and efferent arterioles in renal biopsies from 25 adult patients with IgAN (hypertension at biopsy: 14 patients) and 9 patients with BNS. Six age-matched living renal transplant donors acted as controls. A systematic independent sample of profiles was obtained in thin sections taken at predetermined levels. The thickness of the media (myomedial cells plus the matrix) and the thickness of the medial matrix were estimated stereologically. From these estimates, the matrix/myomedia ratio was calculated, In IgAN with normotension or hypertension, the afferent media and its compartments did not exhibit significant thickening compared with the controls, whereas in BNS the afferent media and its layers were markedly and significantly thickened. The efferent media in IgAN and BNS displayed mild and significant thickening, with significant thickening of the matrix in BNS and IgAN with normotension. The matrix/myomedia ratio was not altered significantly in any group. The results indicate that the afferent arterioles are not the main sites of IgAN-related arteriolosclerosis, that arteriolosclerosis in IgAN and arteriolosclerosis in BNS are different lesions, and that increased efferent arteriolar thickness, demonstrated here for the first time in IgAN and BNS, might be a manifestation of angiotensin II-mediated autoregulatory efferent vasoconstriction exerted to maintain the glomerular filtration pressure.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalVirchows Archiv
Volume429
Issue number4-5
Publication statusPublished - 1996

Fingerprint

Nephrosclerosis
Nephritis
Arterioles
Glomerulonephritis
Immunoglobulin A
Arteriolosclerosis
Hypertension
Kidney
Biopsy
Vasoconstriction
Angiotensin II
Tissue Donors
Pressure

Keywords

  • Afferent arteriole
  • Angiotensin II
  • Efferent arteriole
  • Essential hypertension
  • IgA glomerulonephritis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Quantitative ultrastructural study of afferent and efferent arterioles in IgA glomerulonephritis and benign nephrosclerosis. / Rázga, Zsolt; Iványi, B.; Zidar, Nina; Ferluga, Dusan; Sonkodi, S.; Ormos, Jenö.

In: Virchows Archiv, Vol. 429, No. 4-5, 1996, p. 275-281.

Research output: Contribution to journalArticle

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