Quantitative T2/* and T'2 maps during reversible focal cerebral ischemia in rats: Separation of blood oxygenation from nonsusceptibility- based contributions

Matthias Grüne, Ferdi A. Van Dorsten, Wolfram Schwindt, Laszlo Oláh, Mathias Hoehn

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Quantitative imaging contrast is evaluated which allows the selective measurement of the blood oxygenation state during cerebral ischemia within a multiparametric imaging study on rats. In a first step, the ambiguities arising in T2/*-weighted images due to T2/* heterogeneity are eliminated by calculating T2/* maps. Then, 1/T'2 maps are calculated according to 1/T'2 = 1/T2/* - 1/T2 to eliminate nonsusceptibility-induced changes of 1/T2/* after the induction of stroke. This is of particular importance in the presence of vasogenic edema. The changes Δ(1/T'2) after the onset of ischemia selectively quantify the variations of the deoxyhemoglobin content during the development of the infarct. The presented results are not available from conventionally recorded parameters of a stroke study and, together with perfusion-weighted images, form a powerful combination to analyze the oxygen consumption and the metabolism of the tissue.

Original languageEnglish
Pages (from-to)1027-1032
Number of pages6
JournalMagnetic Resonance in Medicine
Volume42
Issue number6
DOIs
Publication statusPublished - Jan 1 1999

Keywords

  • Cerebral blood oxygenation
  • Focal cerebral ischemia
  • Quantitative T/* and R' MRI
  • Rat brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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