Quantitative MRI studies of chronic brain white matter hyperintensities in migraine patients

Mihály Aradi, Attila Schwarcz, Gábor Perlaki, Gergely Orsi, N. Kovács, Anita Trauninger, David Olayinka Kamson, Szilvia Erdélyi-Bótor, Ferenc Nagy, Szilvia Anett Nagy, T. Dóczi, S. Komoly, Zoltán Pfund

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective The aim of this study was to examine chronic brain white matter hyperintensities in migraine and to gain data on the characteristics of the lesions. Background Migraine associates with a higher incidence of magnetic resonance imaging (MRI)-visible white matter signal abnormalities. Several attack-related pathomechanisms have been proposed in the lesion development, including the effect of repeated intracerebral hemodynamic changes. Methods Supratentorial white matter hyperintensities of 17 migraine patients were investigated interictally with quantitative MRI, including quantitative single voxel spectroscopy, diffusion, and perfusion MRI at 3.0-Tesla. The findings were compared with data measured in the contralateral, normal-appearing white matter of migraineurs and in the white matter of 17 healthy subjects. Results Significantly higher apparent diffusion coefficient values, prolonged T2 relaxation times, and decreased N-acetyl-aspartate and creatine/phosphocreatine concentrations were found in the white matter hyperintensities. The cerebral blood flow and blood volume values were mildly decreased inside the hyperintensities. Differences were not present between the migraine patients' normal-appearing white matter and the white matter of healthy subjects. Conclusions The MRI measurements denote tissue damage with axonal loss, low glial cell density, and an enlarged extracellular space with an increased extracellular water fraction. These radiological features might be the consequences of microvascular ischemic changes during migraine attacks.

Original languageEnglish
Pages (from-to)752-763
Number of pages12
JournalHeadache
Volume53
Issue number5
DOIs
Publication statusPublished - May 2013

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Migraine Disorders
Magnetic Resonance Imaging
Brain
Cerebrovascular Circulation
Healthy Volunteers
Diffusion Magnetic Resonance Imaging
Phosphocreatine
White Matter
Creatine
Magnetic Resonance Angiography
Extracellular Space
Blood Volume
Neuroglia
Spectrum Analysis
Cell Count
Hemodynamics
Water
Incidence

Keywords

  • brain white matter hyperintensity
  • migraine
  • quantitative 3.0-Tesla magnetic resonance imaging
  • repeated hemodynamic change

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Aradi, M., Schwarcz, A., Perlaki, G., Orsi, G., Kovács, N., Trauninger, A., ... Pfund, Z. (2013). Quantitative MRI studies of chronic brain white matter hyperintensities in migraine patients. Headache, 53(5), 752-763. https://doi.org/10.1111/head.12013

Quantitative MRI studies of chronic brain white matter hyperintensities in migraine patients. / Aradi, Mihály; Schwarcz, Attila; Perlaki, Gábor; Orsi, Gergely; Kovács, N.; Trauninger, Anita; Kamson, David Olayinka; Erdélyi-Bótor, Szilvia; Nagy, Ferenc; Nagy, Szilvia Anett; Dóczi, T.; Komoly, S.; Pfund, Zoltán.

In: Headache, Vol. 53, No. 5, 05.2013, p. 752-763.

Research output: Contribution to journalArticle

Aradi, M, Schwarcz, A, Perlaki, G, Orsi, G, Kovács, N, Trauninger, A, Kamson, DO, Erdélyi-Bótor, S, Nagy, F, Nagy, SA, Dóczi, T, Komoly, S & Pfund, Z 2013, 'Quantitative MRI studies of chronic brain white matter hyperintensities in migraine patients', Headache, vol. 53, no. 5, pp. 752-763. https://doi.org/10.1111/head.12013
Aradi, Mihály ; Schwarcz, Attila ; Perlaki, Gábor ; Orsi, Gergely ; Kovács, N. ; Trauninger, Anita ; Kamson, David Olayinka ; Erdélyi-Bótor, Szilvia ; Nagy, Ferenc ; Nagy, Szilvia Anett ; Dóczi, T. ; Komoly, S. ; Pfund, Zoltán. / Quantitative MRI studies of chronic brain white matter hyperintensities in migraine patients. In: Headache. 2013 ; Vol. 53, No. 5. pp. 752-763.
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