Quantitative estimation of activities of mutant enzymes

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9 Citations (Scopus)


A simple equation is presented for the prediction of catalytic efficiencies and Michaelis constants for pairs of mutant serine proteases and substrates with variable P1 side chains. The equation is a generalization of the "similis simili gaudet" principle formulated by Gráf et al. [3] (Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 4961, stating that in water amino-acid side chains with similar polarities tend to Interact stronger than dissimilar ones.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalCatalysis Letters
Issue number3
Publication statusPublished - May 1 1989

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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