Quantitative EEG abnormalities in persons with "pure" epileptic predisposition without epilepsy: A low resolution electromagnetic tomography (LORETA) study

S. Puskás, M. Bessenyei, I. Fekete, K. Hollódy, B. Clemens

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: Epileptic predisposition means genetically determined, increased seizure susceptibility. Neurophysiological evaluation of this condition is still lacking. In order to investigate " pure epileptic predisposition" (without epilepsy) in this pilot study the authors prospectively recruited ten persons who displayed generalized tonic-clonic seizures precipitated by 24 or more hours of sleep deprivation but were healthy in any other respects. Methods: 21-channel EEGs were recorded in the morning, in the waking state, after a night of sufficient sleep in the interictal period. For each person, a total of 120. s artifact-free EEG was processed to low resolution electromagnetic tomography (LORETA) analysis. LORETA activity (Ampers/meters squared) was computed for 2394 voxels, 19 active electrodes and 1. Hz very narrow bands from 1 to 25. Hz. The data were compressed into four frequency bands (δ: 0.5-4.0. Hz, θ: 4.5-8.0. Hz, α: 8.5-12.0. Hz, β: 12.5-25.0. Hz) and projected onto the MRI figures of a digitized standard brain atlas. The band-related LORETA results were compared to those of ten, age- and sex-matched healthy persons using independent t-tests. p

Original languageEnglish
Pages (from-to)94-100
Number of pages7
JournalEpilepsy Research
Volume91
Issue number1
DOIs
Publication statusPublished - Sep 2010

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Electromagnetic Phenomena
Electroencephalography
Epilepsy
Tomography
Seizures
Sleep Deprivation
Atlases
Artifacts
Sleep
Electrodes
Brain

Keywords

  • EEG
  • Epilepsy
  • Epileptic predisposition
  • LORETA

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Quantitative EEG abnormalities in persons with "pure" epileptic predisposition without epilepsy : A low resolution electromagnetic tomography (LORETA) study. / Puskás, S.; Bessenyei, M.; Fekete, I.; Hollódy, K.; Clemens, B.

In: Epilepsy Research, Vol. 91, No. 1, 09.2010, p. 94-100.

Research output: Contribution to journalArticle

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