Quantitative constraints on the scope of negative selection

Viktor Müller, Sebastian Bonhoeffer

Research output: Contribution to journalArticle

16 Citations (Scopus)


Maturing T cells with a high affinity for self-antigens presented in the thymus are deleted in the process of negative selection. Although the expression of various 'tissue-specific' antigens has been described in the thymus, it is still controversial what fraction of all self-antigens induces tolerance by this mechanism. We demonstrate that the limited duration of the negative selection phase imposes a constraint on the number of self-peptides that can be reliably selected against. The analysis supports the theory that negative selection is confined to the subset of peptides produced by dendritic cells.

Original languageEnglish
Pages (from-to)132-135
Number of pages4
JournalTrends in Immunology
Issue number3
Publication statusPublished - Mar 1 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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