Quantitative constraints on the scope of negative selection

V. Müller, Sebastian Bonhoeffer

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Maturing T cells with a high affinity for self-antigens presented in the thymus are deleted in the process of negative selection. Although the expression of various 'tissue-specific' antigens has been described in the thymus, it is still controversial what fraction of all self-antigens induces tolerance by this mechanism. We demonstrate that the limited duration of the negative selection phase imposes a constraint on the number of self-peptides that can be reliably selected against. The analysis supports the theory that negative selection is confined to the subset of peptides produced by dendritic cells.

Original languageEnglish
Pages (from-to)132-135
Number of pages4
JournalTrends in Immunology
Volume24
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

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Autoantigens
Thymus Gland
Peptides
Dendritic Cells
T-Lymphocytes
Antigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Quantitative constraints on the scope of negative selection. / Müller, V.; Bonhoeffer, Sebastian.

In: Trends in Immunology, Vol. 24, No. 3, 01.03.2003, p. 132-135.

Research output: Contribution to journalArticle

Müller, V. ; Bonhoeffer, Sebastian. / Quantitative constraints on the scope of negative selection. In: Trends in Immunology. 2003 ; Vol. 24, No. 3. pp. 132-135.
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