Quantitative assessment of brain iron by R2* relaxometry in patients with cervical dystonia

Zsuzsanna Aschermann, Gabor Perlaki, Gergely Orsi, Szilvia Anett Nagy, Andrea Horvath, Beata Bone, Katalin Bihari, Peter Acs, J. Janszky, S. Komoly, P. Bogner

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The pathophysiology of cervical dystonia is poorly understood. Increased brain iron deposition has been described in different movement disorders. Our aim was to investigate brain iron content in patients with cervical dystonia, using R2* relaxation rate, a validated MRI marker of brain iron level. Methods: Twelve female patients with primary focal cervical dystonia (mean age: 45.4±8.0 years) and 12 age-matched healthy female subjects (mean age: 45.0±8.0 years) underwent 3T MRI to obtain regional R2* relaxation rates of the thalamus, caudate nucleus, putamen, and globus pallidus (GP). Regions of interest were delineated automatically on T1-weighted MRIs. Results: R2* values in the putamen were positively correlated with age. Patients with cervical dystonia showed elevated R2* values in the GP. Conclusions: This pilot study provides the first quantitative support for increased brain iron deposition in cervical dystonia. Further studies are needed to explore the implications of this finding.

Original languageEnglish
Pages (from-to)1422-1426
Number of pages5
JournalMovement Disorders
Volume30
Issue number10
DOIs
Publication statusPublished - Sep 1 2015

Fingerprint

Torticollis
Iron
Globus Pallidus
Putamen
Brain
Dystonic Disorders
Caudate Nucleus
Movement Disorders
Thalamus
Healthy Volunteers

Keywords

  • Cervical dystonia
  • Iron
  • MRI
  • R2* relaxation rate
  • Torticollis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Quantitative assessment of brain iron by R2* relaxometry in patients with cervical dystonia. / Aschermann, Zsuzsanna; Perlaki, Gabor; Orsi, Gergely; Nagy, Szilvia Anett; Horvath, Andrea; Bone, Beata; Bihari, Katalin; Acs, Peter; Janszky, J.; Komoly, S.; Bogner, P.

In: Movement Disorders, Vol. 30, No. 10, 01.09.2015, p. 1422-1426.

Research output: Contribution to journalArticle

Aschermann, Z, Perlaki, G, Orsi, G, Nagy, SA, Horvath, A, Bone, B, Bihari, K, Acs, P, Janszky, J, Komoly, S & Bogner, P 2015, 'Quantitative assessment of brain iron by R2* relaxometry in patients with cervical dystonia', Movement Disorders, vol. 30, no. 10, pp. 1422-1426. https://doi.org/10.1002/mds.26306
Aschermann Z, Perlaki G, Orsi G, Nagy SA, Horvath A, Bone B et al. Quantitative assessment of brain iron by R2* relaxometry in patients with cervical dystonia. Movement Disorders. 2015 Sep 1;30(10):1422-1426. https://doi.org/10.1002/mds.26306
Aschermann, Zsuzsanna ; Perlaki, Gabor ; Orsi, Gergely ; Nagy, Szilvia Anett ; Horvath, Andrea ; Bone, Beata ; Bihari, Katalin ; Acs, Peter ; Janszky, J. ; Komoly, S. ; Bogner, P. / Quantitative assessment of brain iron by R2* relaxometry in patients with cervical dystonia. In: Movement Disorders. 2015 ; Vol. 30, No. 10. pp. 1422-1426.
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