Quantitative analysis of vasodilatory action of quercetin on intramural coronary resistance arteries of the rat in vitro

Anna Monori-Kiss, E. Monos, G. Nádasy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Dietary quercetin improves cardiovascular health, relaxes some vascular smooth muscle and has been demonstrated to serve as a substrate for the cyclooxygenase enzyme. Aims: 1. To test quantitatively a potential direct vasodilatory effect on intramural coronary resistance artery segments, in different concentrations. 2. To scale vasorelaxation at different intraluminal pressure loads on such vessels of different size. 3. To test the potential role of prostanoids in vasodilatation induced by quercetin. Methods: Coronary arterioles (70-240 μm) were prepared from 24 rats and pressurized in PSS, using a pressure microangiometer. Results: The spontaneous tone that developed at 50 mmHg was relaxed by quercetin in the 10-9 moles/lit concentration (p-5 moles/lit caused full relaxation. Significant relaxation was observed at all pressure levels (10- 100 mmHg) at 10-7 moles/lit concentration of quercetin. The cyclooxygenase blocker indomethacin (10-5moles/lit) induced no relaxation but contraction when physiological concentrations of quercetin were present in the tissue bath (p<0.02 with Anova), this contraction being more prominent in smaller vessels and in the higher pressure range (p-4 moles/lit). Conclusion: These results demonstrate that circulating levels of quercetin (10-7 moles/lit) exhibit a substantial coronary vasodilatory effect. The extent of it is commeasurable with that of several other physiological mechanisms of coronary blood flow control. At least part of this relaxation is the result of an altered balance toward the production of endogenous vasodilatory prostanoids in the coronary arteriole wall.

Original languageEnglish
Article numbere105587
JournalPLoS One
Volume9
Issue number8
DOIs
Publication statusPublished - Aug 21 2014

Fingerprint

Quercetin
quercetin
arteries
quantitative analysis
Rats
Coronary Vessels
rats
Chemical analysis
Pressure
vasodilation
Arterioles
prostaglandin synthase
Prostaglandin-Endoperoxide Synthases
Vasodilation
prostaglandins
Prostaglandins
indomethacin
Baths
Vascular Smooth Muscle
Flow control

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Quantitative analysis of vasodilatory action of quercetin on intramural coronary resistance arteries of the rat in vitro. / Monori-Kiss, Anna; Monos, E.; Nádasy, G.

In: PLoS One, Vol. 9, No. 8, e105587, 21.08.2014.

Research output: Contribution to journalArticle

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