Quantitative analysis of mixtures of drug delivery system components by Raman microscopy

A. Szép, G. Marosi, B. Marosföi, P. Anna, I. Mohammed-Ziegler, M. Virágh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A series of two-component powders and tableted mixtures of corn starch and lactose-monohydrate were prepared and studied using the fiber optic sensor of a LabRam dispersion Raman microscope in order to establish a convenient method for quantitative determination of their concentration based on Raman spectra. The intensities of certain characteristic peaks of the components were used for calculating the calibration curve. Linear calibration curves were found in the concentration range of 10-80% with correlation coefficients of 0.9979-0.9996 for powders and tablets. Chemical mapping of the tablets was also carried out, thus allowing determination of the distribution of the components.

Original languageEnglish
Pages (from-to)784-789
Number of pages6
JournalPolymers for Advanced Technologies
Volume14
Issue number11-12
Publication statusPublished - Nov 2003

Fingerprint

Powders
Tablets
Microscopic examination
Calibration
Fiber optic sensors
Lactose
Chemical analysis
Starch
Raman scattering
Microscopes
Drug Delivery Systems

Keywords

  • Corn starch
  • Fiber optics
  • Homogeneity
  • Lactose-monohydrate
  • Quantitative analysis
  • Raman microscopy

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Quantitative analysis of mixtures of drug delivery system components by Raman microscopy. / Szép, A.; Marosi, G.; Marosföi, B.; Anna, P.; Mohammed-Ziegler, I.; Virágh, M.

In: Polymers for Advanced Technologies, Vol. 14, No. 11-12, 11.2003, p. 784-789.

Research output: Contribution to journalArticle

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AU - Virágh, M.

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