Quantitative analysis of catecholamines in human dental pulp

Gábor Nagy, Yvette Bartha, Tamás Keresztes, Éva Ölveti, Melinda Madléna

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Catecholamines are important elements of neuroendocrine regulation, and their concentrations in dental pulp are of interest. Two groups of teeth were used in this study: (i) healthy teeth and (ii) periodontally diseased teeth. After the processing of dental pulp obtained from the extracted teeth, the samples were analyzed in a computer-controlled Merck-Hitachi HPLC system at 280 nm wavelength. The external and internal standard methods of the HPLC Manager Program were used for validation. In healthy teeth the norepinephrine level of dental pulp was 4.86 ± 0.96 μg/g, whereas the epinephrine level was 8.1 ± 1.18 μg/g. In periodontally diseased teeth norepinephrine and epinephrine levels were significantly higher (p < 0.01) at 13.98 ± 21.13 μg/g and 1.42 ± 0.32 μg/g, respectively. Dopamine could not be demonstrated in 87% of the pulps. Summing up we succeeded in demonstrating norepinephrine and epinephrine in human pulp, but in most cases we could not demonstrate dopamine. Further investigations are needed on pulp tissue infected because of caries.

Original languageEnglish
Article number60891
Pages (from-to)596-598
Number of pages3
JournalJournal of Endodontics
Issue number10
Publication statusPublished - Jan 1 2000


ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Nagy, G., Bartha, Y., Keresztes, T., Ölveti, É., & Madléna, M. (2000). Quantitative analysis of catecholamines in human dental pulp. Journal of Endodontics, 26(10), 596-598. [60891]. https://doi.org/10.1097/00004770-200010000-00005