Quantification of pulmonary blood flow (PBF): Validation of perfusion MRI and nonlinear contrast agent (CA) dose correction with H2 15O positron emission tomography (PET)

Daniel Neeb, Rainer Peter Kunz, Sebastian Ley, G. Szabó, Ludwig G. Strauss, Hans Ulrich Kauczor, Karl Friedrich Kreitner, Laura Maria Schreiber

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Validation of quantification of pulmonary blood flow (PBF) with dynamic, contrast-enhanced MRI is still missing. A possible reason certainly lies in difficulties based on the nonlinear dependence of signal intensity (SI) from contrast agent (CA) concentration. Both aspects were addressed in this study. Nine healthy pigs were examined by first-pass perfusion MRI using gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) and H215O positron emission tomography (PET) imaging. Calculations of hemodynamic parameters were based on a one-compartment model (MR) and a two-compartment model (PET). Simulations showed a significant error when assuming a linear relation between MR SI and CA dose in the arterial input function (AIF), even at low doses of 0.025 mmol/kg body weight (BW). To correct for nonlinearity, a calibration curve was calculated on the basis of the signal equation. The required accuracy of equation parameters (like longitudinal relaxation time) was evaluated. Error analysis estimates

Original languageEnglish
Pages (from-to)476-487
Number of pages12
JournalMagnetic Resonance in Medicine
Volume62
Issue number2
DOIs
Publication statusPublished - Aug 2009

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Positron-Emission Tomography
Contrast Media
Perfusion
Lung
Pentetic Acid
Gadolinium
Calibration
Swine
Hemodynamics
Body Weight

Keywords

  • Magnetic resonance imaging
  • PET
  • Pulmonary perfusion
  • Quantification
  • Validation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Quantification of pulmonary blood flow (PBF) : Validation of perfusion MRI and nonlinear contrast agent (CA) dose correction with H2 15O positron emission tomography (PET). / Neeb, Daniel; Kunz, Rainer Peter; Ley, Sebastian; Szabó, G.; Strauss, Ludwig G.; Kauczor, Hans Ulrich; Kreitner, Karl Friedrich; Schreiber, Laura Maria.

In: Magnetic Resonance in Medicine, Vol. 62, No. 2, 08.2009, p. 476-487.

Research output: Contribution to journalArticle

Neeb, Daniel ; Kunz, Rainer Peter ; Ley, Sebastian ; Szabó, G. ; Strauss, Ludwig G. ; Kauczor, Hans Ulrich ; Kreitner, Karl Friedrich ; Schreiber, Laura Maria. / Quantification of pulmonary blood flow (PBF) : Validation of perfusion MRI and nonlinear contrast agent (CA) dose correction with H2 15O positron emission tomography (PET). In: Magnetic Resonance in Medicine. 2009 ; Vol. 62, No. 2. pp. 476-487.
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