Quantification of particle deposition in asymmetrical tracheobronchial model geometry

Árpád Farkas, I. Balásházy

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The primary objective of this study was to quantify the local inspiratory and expiratory aerosol deposition in a highly asymmetric five-generation tracheobronchial tree. User-enhanced commercial codes and self-developed software was used to compute the air velocity field as well as particle deposition distributions for a large size range of inhalable particles. The numerical model was validated by comparison of our results with experimental flow measurements and particle deposition data available in the open literature. Our simulations show highly localised deposition patterns for all particle sizes, but mainly for the larger particles. As expected, deposition efficiencies and deposition fractions proved to be very sensitive to the particle size. The deposition density in the hot spots can be hundreds and even thousand times higher than the mean deposition density. Present results can be of interest to researchers involved in the assessment of adverse health effects of inhaled aerosols or optimising the drug aerosol delivery into the lung.

Original languageEnglish
Pages (from-to)508-518
Number of pages11
JournalComputers in Biology and Medicine
Volume38
Issue number4
DOIs
Publication statusPublished - Apr 2008

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Aerosols
Particle Size
Geometry
Software
Air
Research Personnel
Lung
Particle size
Health
Pharmaceutical Preparations
Flow measurement
Numerical models

Keywords

  • Airflow
  • Central airways
  • Computational fluid and particle dynamics
  • Deposition efficiency
  • Deposition enhancement factor
  • Deposition fraction
  • Particle deposition patterns

ASJC Scopus subject areas

  • Computer Science Applications

Cite this

Quantification of particle deposition in asymmetrical tracheobronchial model geometry. / Farkas, Árpád; Balásházy, I.

In: Computers in Biology and Medicine, Vol. 38, No. 4, 04.2008, p. 508-518.

Research output: Contribution to journalArticle

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