Quantification of airway deposition of intact and fragmented pollens

Alpár Horváth, Imre Balásházy, Árpád Farkas, Zoltán Sárkány, Werner Hofmann, Aladár Czitrovszky, Erik Dobos

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Although pollen is one of the most widespread agents that can cause allergy, its airway transport and deposition is far from being fully explored. The objective of this study was to characterize the airway deposition of pollens and to contribute to the debate related to the increasing number of asthma attacks registered after thunderstorms. For the quantification of the deposition of inhaled pollens in the airways computer simulations were performed. Our results demonstrated that smaller and fragmented pollens may penetrate into the thoracic airways and deposit there, supporting the theory that fragmented pollen particles are responsible for the increasing incidence of asthma attacks following thunderstorms. Pollen deposition results also suggest that children are the most exposed to the allergic effects of pollens. Finally, pollens between 0.5 and 20 μm deposit more efficiently in the lung of asthmatics than in the healthy lung, especially in the bronchial region.

Original languageEnglish
Pages (from-to)427-440
Number of pages14
JournalInternational Journal of Environmental Health Research
Volume21
Issue number6
DOIs
Publication statusPublished - Dec 1 2011

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Keywords

  • Airway deposition of pollens
  • Asthma modelling
  • Monte Carlo simulations

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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