Quantification of airway deposition of intact and fragmented pollens

Alpár Horváth, I. Balásházy, Árpád Farkas, Zoltán Sárkány, Werner Hofmann, Aladár Czitrovszky, Erik Dobos

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Although pollen is one of the most widespread agents that can cause allergy, its airway transport and deposition is far from being fully explored. The objective of this study was to characterize the airway deposition of pollens and to contribute to the debate related to the increasing number of asthma attacks registered after thunderstorms. For the quantification of the deposition of inhaled pollens in the airways computer simulations were performed. Our results demonstrated that smaller and fragmented pollens may penetrate into the thoracic airways and deposit there, supporting the theory that fragmented pollen particles are responsible for the increasing incidence of asthma attacks following thunderstorms. Pollen deposition results also suggest that children are the most exposed to the allergic effects of pollens. Finally, pollens between 0.5 and 20 μm deposit more efficiently in the lung of asthmatics than in the healthy lung, especially in the bronchial region.

Original languageEnglish
Pages (from-to)427-440
Number of pages14
JournalInternational Journal of Environmental Health Research
Volume21
Issue number6
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Pollen
Thunderstorms
Deposits
Allergies
Asthma
Lung
Computer simulation
Computer Simulation
Hypersensitivity
Thorax
Incidence

Keywords

  • Airway deposition of pollens
  • Asthma modelling
  • Monte Carlo simulations

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pollution
  • Public Health, Environmental and Occupational Health

Cite this

Quantification of airway deposition of intact and fragmented pollens. / Horváth, Alpár; Balásházy, I.; Farkas, Árpád; Sárkány, Zoltán; Hofmann, Werner; Czitrovszky, Aladár; Dobos, Erik.

In: International Journal of Environmental Health Research, Vol. 21, No. 6, 12.2011, p. 427-440.

Research output: Contribution to journalArticle

Horváth, Alpár ; Balásházy, I. ; Farkas, Árpád ; Sárkány, Zoltán ; Hofmann, Werner ; Czitrovszky, Aladár ; Dobos, Erik. / Quantification of airway deposition of intact and fragmented pollens. In: International Journal of Environmental Health Research. 2011 ; Vol. 21, No. 6. pp. 427-440.
@article{36069f4c5bb544839f1c606637909675,
title = "Quantification of airway deposition of intact and fragmented pollens",
abstract = "Although pollen is one of the most widespread agents that can cause allergy, its airway transport and deposition is far from being fully explored. The objective of this study was to characterize the airway deposition of pollens and to contribute to the debate related to the increasing number of asthma attacks registered after thunderstorms. For the quantification of the deposition of inhaled pollens in the airways computer simulations were performed. Our results demonstrated that smaller and fragmented pollens may penetrate into the thoracic airways and deposit there, supporting the theory that fragmented pollen particles are responsible for the increasing incidence of asthma attacks following thunderstorms. Pollen deposition results also suggest that children are the most exposed to the allergic effects of pollens. Finally, pollens between 0.5 and 20 μm deposit more efficiently in the lung of asthmatics than in the healthy lung, especially in the bronchial region.",
keywords = "Airway deposition of pollens, Asthma modelling, Monte Carlo simulations",
author = "Alp{\'a}r Horv{\'a}th and I. Bal{\'a}sh{\'a}zy and {\'A}rp{\'a}d Farkas and Zolt{\'a}n S{\'a}rk{\'a}ny and Werner Hofmann and Alad{\'a}r Czitrovszky and Erik Dobos",
year = "2011",
month = "12",
doi = "10.1080/09603123.2011.574269",
language = "English",
volume = "21",
pages = "427--440",
journal = "International Journal of Environmental Health Research",
issn = "0960-3123",
publisher = "Taylor and Francis Ltd.",
number = "6",

}

TY - JOUR

T1 - Quantification of airway deposition of intact and fragmented pollens

AU - Horváth, Alpár

AU - Balásházy, I.

AU - Farkas, Árpád

AU - Sárkány, Zoltán

AU - Hofmann, Werner

AU - Czitrovszky, Aladár

AU - Dobos, Erik

PY - 2011/12

Y1 - 2011/12

N2 - Although pollen is one of the most widespread agents that can cause allergy, its airway transport and deposition is far from being fully explored. The objective of this study was to characterize the airway deposition of pollens and to contribute to the debate related to the increasing number of asthma attacks registered after thunderstorms. For the quantification of the deposition of inhaled pollens in the airways computer simulations were performed. Our results demonstrated that smaller and fragmented pollens may penetrate into the thoracic airways and deposit there, supporting the theory that fragmented pollen particles are responsible for the increasing incidence of asthma attacks following thunderstorms. Pollen deposition results also suggest that children are the most exposed to the allergic effects of pollens. Finally, pollens between 0.5 and 20 μm deposit more efficiently in the lung of asthmatics than in the healthy lung, especially in the bronchial region.

AB - Although pollen is one of the most widespread agents that can cause allergy, its airway transport and deposition is far from being fully explored. The objective of this study was to characterize the airway deposition of pollens and to contribute to the debate related to the increasing number of asthma attacks registered after thunderstorms. For the quantification of the deposition of inhaled pollens in the airways computer simulations were performed. Our results demonstrated that smaller and fragmented pollens may penetrate into the thoracic airways and deposit there, supporting the theory that fragmented pollen particles are responsible for the increasing incidence of asthma attacks following thunderstorms. Pollen deposition results also suggest that children are the most exposed to the allergic effects of pollens. Finally, pollens between 0.5 and 20 μm deposit more efficiently in the lung of asthmatics than in the healthy lung, especially in the bronchial region.

KW - Airway deposition of pollens

KW - Asthma modelling

KW - Monte Carlo simulations

UR - http://www.scopus.com/inward/record.url?scp=84856147846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856147846&partnerID=8YFLogxK

U2 - 10.1080/09603123.2011.574269

DO - 10.1080/09603123.2011.574269

M3 - Article

C2 - 21563012

AN - SCOPUS:84856147846

VL - 21

SP - 427

EP - 440

JO - International Journal of Environmental Health Research

JF - International Journal of Environmental Health Research

SN - 0960-3123

IS - 6

ER -