Qualitative analysis of a closed-loop model of tumor growth control

Dániel András Drexler, Ilona Nagy, Valery Romanovski, János Tóth, Levente Kovács

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Tumor volume modeling and control is a promising way to design more efficient, personalized tumor treatment. This requires a model of tumor growth dynamics, and a control law to design the therapy. Tumor growth models are usually nonlinear, while most control laws are linear, and the controllers are designed for approximate linear models thus stable operation is guaranteed only locally. We consider the application of a linear state feedback for a nonlinear tumor growth model, and carry out the qualitative analysis of the closed-loop model. We give conditions for the control law parameters to have a globally stable closed-loop system, and analyze the effect of the control law parameters on the steady-state tumor volume and the maximal drug injection.

Original languageEnglish
Title of host publication18th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2018 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages329-334
Number of pages6
ISBN (Electronic)9781728111179
DOIs
Publication statusPublished - Nov 2018
Event18th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2018 - Budapest, Hungary
Duration: Nov 21 2018Nov 22 2018

Publication series

Name18th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2018 - Proceedings

Conference

Conference18th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2018
CountryHungary
CityBudapest
Period11/21/1811/22/18

Keywords

  • cancer therapy
  • tumor control
  • tumor therapy

ASJC Scopus subject areas

  • Artificial Intelligence
  • Computer Science Applications
  • Information Systems
  • Information Systems and Management
  • Computational Mathematics
  • Modelling and Simulation

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  • Cite this

    Drexler, D. A., Nagy, I., Romanovski, V., Tóth, J., & Kovács, L. (2018). Qualitative analysis of a closed-loop model of tumor growth control. In 18th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2018 - Proceedings (pp. 329-334). [8928208] (18th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2018 - Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CINTI.2018.8928208