Pyrone derivatives from Helichrysum italicum

Julia Werner, Weaam Ebrahim, Ferhat Can Özkaya, Attila Mándi, T. Kurtán, Mona El-Neketi, Zhen Liu, Peter Proksch

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Chemical investigation of aerial parts of Helichrysum italicum yielded two new pyrone derivatives (1 and 2) along with ten known compounds. The structures of the new compounds were established by 1D and 2D NMR spectra as well as by HRESIMS data. Compound 1 represented a rare dimer of substituted α- and γ-pyrone units. DFT-NMR and TDDFT-ECD calculations were carried out to determine the absolute configuration of 1 but failed, representing the limitation of TDDFT-ECD calculation for the configurational assignment. All compounds were measured for their antibacterial and cytotoxic activity but proved to be inactive.

Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalFitoterapia
Volume133
DOIs
Publication statusPublished - Mar 1 2019

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Helichrysum
Pyrones

Keywords

  • ECD calculations
  • Helichrysum italicum
  • Pyrone

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Werner, J., Ebrahim, W., Özkaya, F. C., Mándi, A., Kurtán, T., El-Neketi, M., ... Proksch, P. (2019). Pyrone derivatives from Helichrysum italicum. Fitoterapia, 133, 80-84. https://doi.org/10.1016/j.fitote.2018.12.018

Pyrone derivatives from Helichrysum italicum. / Werner, Julia; Ebrahim, Weaam; Özkaya, Ferhat Can; Mándi, Attila; Kurtán, T.; El-Neketi, Mona; Liu, Zhen; Proksch, Peter.

In: Fitoterapia, Vol. 133, 01.03.2019, p. 80-84.

Research output: Contribution to journalArticle

Werner, J, Ebrahim, W, Özkaya, FC, Mándi, A, Kurtán, T, El-Neketi, M, Liu, Z & Proksch, P 2019, 'Pyrone derivatives from Helichrysum italicum', Fitoterapia, vol. 133, pp. 80-84. https://doi.org/10.1016/j.fitote.2018.12.018
Werner J, Ebrahim W, Özkaya FC, Mándi A, Kurtán T, El-Neketi M et al. Pyrone derivatives from Helichrysum italicum. Fitoterapia. 2019 Mar 1;133:80-84. https://doi.org/10.1016/j.fitote.2018.12.018
Werner, Julia ; Ebrahim, Weaam ; Özkaya, Ferhat Can ; Mándi, Attila ; Kurtán, T. ; El-Neketi, Mona ; Liu, Zhen ; Proksch, Peter. / Pyrone derivatives from Helichrysum italicum. In: Fitoterapia. 2019 ; Vol. 133. pp. 80-84.
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