Hepatic porphyria and histologically verified cirrhosis, teleangiectasia, purpose, papular skin lesions existing for 8 yr, as well as cryomacroglobulin were found in a 49 yr old man. Pathogenetically the liver disease is considered to be the primary event, which was accompanied by secondary cryoglobulinemia. IgG and IgM type of thrombus in the vessels and of small granular deposits corresponding to the type of cryoprotein in the blood, were detected in the vessel walls of the upper part in the dermis and along these vessels of both purpuri and papular skin lesions. Immunoprecipitates could be revealed by FTC-labelled antihuman complement. In the skin lesions porphyrin could not be demonstrated. The investigation of cryoglobulin and of porphyrin disorders is reasonable in every patient with purpura accompanying pathological liver processes.
|Translated title of the contribution||Purpura kryomacroglobulinemica with liver cirrhosis and hepatic porphyria|
|Number of pages||5|
|Publication status||Published - Dec 1 1977|
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