Purinergic Signalling in Parkinson’s Disease: A Multi-target System to Combat Neurodegeneration

Adrián Tóth, Zsófia Antal, Dániel Bereczki, Beáta Sperlágh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by progressive loss of dopaminergic neurons that results in characteristic motor and non-motor symptoms. l-3,4 dihydroxyphenylalanine (l-DOPA) is the gold standard therapy for the treatment of PD. However, long-term use of l-DOPA leads to side effects such as dyskinesias and motor fluctuation. Since purines have neurotransmitter and co-transmitter properties, the function of the purinergic system has been thoroughly studied in the nervous system. Adenosine and adenosine 5′-triphosphate (ATP) are modulators of dopaminergic neurotransmission, neuroinflammatory processes, oxidative stress, excitotoxicity and cell death via purinergic receptor subtypes. Aberrant purinergic receptor signalling can be either the cause or the result of numerous pathological conditions, including neurodegenerative disorders. Many data confirm the involvement of purinergic signalling pathways in PD. Modulation of purinergic receptor subtypes, the activity of ectonucleotidases and ATP transporters could be beneficial in the treatment of PD. We give a brief summary of the background of purinergic signalling focusing on its roles in PD. Possible targets for pharmacological treatment are highlighted.

Original languageEnglish
Pages (from-to)2413-2422
Number of pages10
JournalNeurochemical research
Volume44
Issue number10
DOIs
Publication statusPublished - Oct 1 2019

Keywords

  • ATP
  • Adenosine
  • Adenosine receptors
  • Parkinson’s disease
  • Purinergic receptors

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Purinergic Signalling in Parkinson’s Disease: A Multi-target System to Combat Neurodegeneration'. Together they form a unique fingerprint.

  • Cite this