Purinergic signalling-evoked intracellular Ca2+ concentration changes in the regulation of chondrogenesis and skeletal muscle formation

Csaba Matta, János Fodor, L. Csernoch, Róza Zákány

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

It is now widely recognised that changes of the intracellular calcium concentration have deep impact on the differentiation of various non-excitable cells including the elements of the vertebrate skeleton. It has become evident that purinergic signalling is one of the most ancient cellular mechanisms that can cause such alterations in the intracellular Ca2+-homeostasis, which are precisely set either spatially or temporally. Purinergic signalling is believed to regulate intracellular Ca2+-concentration of developing cartilage and skeletal muscle cells and suggested to play roles in the modulation of various cellular functions. This idea is supported by the fact that pluripotent mesenchymal cells, chondroprogenitors or muscle precursors, as well as mature chondrocytes all are capable of releasing ectonucleotides, and express various types of purinoreceptors and ectonucleotidases. The presence of the basic components of purinergic signalling proves that cells of the chondrogenic lineage can utilise this mechanism for modulating their intracellular Ca2+ concentration independently from the surrounding skeletal muscle and bone tissues, which are well known to release ectopurines during development and mechanical stress. In this review, we summarize accumulating experimental evidence supporting the importance of purinergic signalling in the regulation of chondrogenesis and during skeletal muscle formation.

Original languageEnglish
JournalCell Calcium
DOIs
Publication statusAccepted/In press - Oct 16 2015

Fingerprint

Chondrogenesis
Skeletal Muscle
Muscles
Mechanical Stress
Cell Lineage
Chondrocytes
Skeleton
Muscle Cells
Cartilage
Vertebrates
Homeostasis
Calcium
Bone and Bones

Keywords

  • ATP
  • Ca-oscillations
  • Cartilage formation
  • Mesenchymal stem cells
  • Myogenesis
  • Purinoreceptor

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

Purinergic signalling-evoked intracellular Ca2+ concentration changes in the regulation of chondrogenesis and skeletal muscle formation. / Matta, Csaba; Fodor, János; Csernoch, L.; Zákány, Róza.

In: Cell Calcium, 16.10.2015.

Research output: Contribution to journalArticle

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