Purine ionotropic (P2X) receptors

L. Köles, S. Fürst, Peter Illés

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Purinergic signaling is involved in the proper functioning of virtually all organs of the body. Although in some cases purines have a major influence on physiological functions (e.g. thrombocyte aggregation), more often they are just background modulators contributing to the fine tuning of biological events. However, under pathological conditions, when a huge amount of adenosine 5′-triphosphate (ATP) can reach the extracellular space, their significance is increasing. ATP and its various degradation products activate membrane receptors divided into two main classes: the metabotropic P2Y and the ionotropic P2X family. This latter group, the purine ionotropic receptor, is the objects of this review. After providing a description about the distribution and functional properties of P2X receptors in the body, their pharmacology will be summarized. In the second part of this review, the role of purines in those organ systems and body functions will be highlighted, where the (patho)physiological role of P2x receptors has been suggested or is even well established. Besides the regulation of organ systems, for instance in the cardiovascular, respiratory, genitourinary or gastrointestinal system, some special issues will also be discussed, such as the role of P2X receptors in pain, tumors, central nervour system (CNS) injury and embryonic development. Several examples will indicate that purine ionotropic receptors might serve as attractive targets for pharmacological interventions in various diseases, and that selective ligands for these receptors will probably constitute importance future therapeutic tools in humans.

Original languageEnglish
Pages (from-to)2368-2384
Number of pages17
JournalCurrent Pharmaceutical Design
Volume13
Issue number23
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Purinergic Receptors
Purines
Adenosine Triphosphate
Pharmacology
Nociceptors
Extracellular Space
Embryonic Development
Blood Platelets
Ligands
Membranes
Wounds and Injuries
Neoplasms
purine
Therapeutics

Keywords

  • P2X receptor
  • Pathophysiology
  • Pharmacotherapy
  • Purinergic

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Purine ionotropic (P2X) receptors. / Köles, L.; Fürst, S.; Illés, Peter.

In: Current Pharmaceutical Design, Vol. 13, No. 23, 08.2007, p. 2368-2384.

Research output: Contribution to journalArticle

Köles, L. ; Fürst, S. ; Illés, Peter. / Purine ionotropic (P2X) receptors. In: Current Pharmaceutical Design. 2007 ; Vol. 13, No. 23. pp. 2368-2384.
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