Abstract
Anticancer drugs executing their function intracellularly enter cancer cells via diffusive processes. Complementary to these slow processes, cells can be forced to incorporate drugs by convection - a more efficient transport process. Transmembrane convection is induced by moderately intense pulsed laser light (or light emitting diodes) changing the structure of nanoscopic water layers in cells. This is a fundamental difference with the method of photodynamic therapy. In a model system we demonstrate that a total irradiation time of one minute is sufficient to completely inhibit proliferation of cancer cells. Transmembrane convection protects healthy cells from extended chemotherapy exposure, could be exploited to overcome multidrug resistance, and is a promising new tool in a variety of therapies as well as in skin rejuvenation.
| Original language | English |
|---|---|
| Pages (from-to) | 169-173 |
| Number of pages | 5 |
| Journal | Artificial Cells, Blood Substitutes, and Immobilization Biotechnology |
| Volume | 39 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 2011 |
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Keywords
- cancer
- cells
- cytostatic
- cytotoxic
- intracellular interfaces
- laser
- light emitting diodes
- transmembrane convection
ASJC Scopus subject areas
- Biomedical Engineering
- Biotechnology
Cite this
Pulsed laser light forces cancer cells to absorb anticancer drugs - The role of water in nanomedicine. / Sommer, Andrei P.; Zhu, Dan; Mester, A.; Föarsterling, Horst Dieter.
In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, Vol. 39, No. 3, 06.2011, p. 169-173.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pulsed laser light forces cancer cells to absorb anticancer drugs - The role of water in nanomedicine
AU - Sommer, Andrei P.
AU - Zhu, Dan
AU - Mester, A.
AU - Föarsterling, Horst Dieter
PY - 2011/6
Y1 - 2011/6
N2 - Anticancer drugs executing their function intracellularly enter cancer cells via diffusive processes. Complementary to these slow processes, cells can be forced to incorporate drugs by convection - a more efficient transport process. Transmembrane convection is induced by moderately intense pulsed laser light (or light emitting diodes) changing the structure of nanoscopic water layers in cells. This is a fundamental difference with the method of photodynamic therapy. In a model system we demonstrate that a total irradiation time of one minute is sufficient to completely inhibit proliferation of cancer cells. Transmembrane convection protects healthy cells from extended chemotherapy exposure, could be exploited to overcome multidrug resistance, and is a promising new tool in a variety of therapies as well as in skin rejuvenation.
AB - Anticancer drugs executing their function intracellularly enter cancer cells via diffusive processes. Complementary to these slow processes, cells can be forced to incorporate drugs by convection - a more efficient transport process. Transmembrane convection is induced by moderately intense pulsed laser light (or light emitting diodes) changing the structure of nanoscopic water layers in cells. This is a fundamental difference with the method of photodynamic therapy. In a model system we demonstrate that a total irradiation time of one minute is sufficient to completely inhibit proliferation of cancer cells. Transmembrane convection protects healthy cells from extended chemotherapy exposure, could be exploited to overcome multidrug resistance, and is a promising new tool in a variety of therapies as well as in skin rejuvenation.
KW - cancer
KW - cells
KW - cytostatic
KW - cytotoxic
KW - intracellular interfaces
KW - laser
KW - light emitting diodes
KW - transmembrane convection
UR - http://www.scopus.com/inward/record.url?scp=79956159568&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79956159568&partnerID=8YFLogxK
U2 - 10.3109/10731199.2010.516262
DO - 10.3109/10731199.2010.516262
M3 - Article
C2 - 20849242
AN - SCOPUS:79956159568
VL - 39
SP - 169
EP - 173
JO - Artificial Cells, Nanomedicine and Biotechnology
JF - Artificial Cells, Nanomedicine and Biotechnology
SN - 2169-1401
IS - 3
ER -