Pulse wave velocity in end-stage renal disease: Influence of age and body dimensions

Éva Kis, Orsolya Cseprekál, Zsófia Horváth, Gábor Katona, Bertalan C. Fekete, Erzsébet Hrapka, András Szabó, Attila J. Szabó, Andrea Fekete, György S. Reusz

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Abstract

Arterial stiffness increases with age. This process is accelerated by end-stage renal disease (ESRD). Pulse wave velocity (PWV) increases with arterial stiffness. In this study, PWV of 133 healthy individuals (6-23 y of age) and 11 patients on dialysis was measured to establish the normal values of PWV and to compare them with those in ESRD. Age-matched (A-C) and height- and weight-matched (H/W-C) control groups were used. Thereafter, PWV was indexed to height and the data were reevaluated. The role of the risk factors including serum calcium, phosphate, parathyroid hormone (PTH), and the time on dialysis was analyzed using a score system. PWV correlated with age, weight, height, blood pressure, and heart rate. ESRD patients were smaller than A-C and older than H/W-C. PWV of patients with ESRD did not differ from A-C; however, it was elevated in comparison to H/W-C. In both healthy and ESRD patients, the PWV/height ratio was independent of age. PWV/height was increased in ESRD. There was a correlation between PWV/height and the risk factor score. Controls matched for height and weight or PWV/height should be used in cases of growth failure. A number of risk factors responsible for increased arterial stiffness are present in ESRD.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalPediatric research
Volume63
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Kis, É., Cseprekál, O., Horváth, Z., Katona, G., Fekete, B. C., Hrapka, E., Szabó, A., Szabó, A. J., Fekete, A., & Reusz, G. S. (2008). Pulse wave velocity in end-stage renal disease: Influence of age and body dimensions. Pediatric research, 63(1), 95-98. https://doi.org/10.1203/PDR.0b013e31815b47ff