Pulsatile gonadotropin releasing hormone substitution following extirpation of suprasellar craniopharyngioma

Sándor Koloszár, G. Bártfai

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Abstract

A craniopharyngioma growing suprasellarly attacks the medio-basal region of the hypothalamus, interrupting the production of gonadotropin-releasing hormone. In the case of a 15-year-old girl who underwent partial extirpation of craniopharyngioma, favorable endocrine effects were obtained by pulsatile gonadotropin-releasing hormone treatment. Gonadotropin-releasing hormone administered in a dose of 20 μg every 90 min resulted in the achievement of a menstrual cycle and ovulation. Together with surgical treatment, hormonal substitution plays an important role in the treatment of endocrine symptoms.

Original languageEnglish
Pages (from-to)753-756
Number of pages4
JournalJournal of Endocrinological Investigation: Official Journal of the Italian Society of Endocrinology
Volume13
Issue number9
DOIs
Publication statusPublished - Oct 1990

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Keywords

  • Craniopharyngioma
  • gonadotropin-releasing hormone
  • pulsatile infusion

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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