An ideal method for measuring cerebral blood flow (CBF), should give values for total CBF or CBF in ml.100g-1.min-1; be suited for measuring CBF in unanaesthetized, unrestrained animals; permit continuous measurement of CBF; and be applicable to circumscribed areas of the brain. No method available so far fulfils all the criteria listed; at most, three of the requirements could be complied with by any of the methods. Measurement of electrical impedance pulsations in the brain, the so called pulsatile cerebral impedance (PCI), has proved sensitive to changes in cerebral circulation. The method yielded new information on brain haemodynamics, such as elective vasodilation in the hypothalamus during arousal in the cat (Birzis et al. 1968). A modification of the method of Birzis and Tachibana is described in experiments on rats. Effects of hypercapnia and hypoxia on the amplitude of pulsatile cerebral impedance are demonstrated.
|Number of pages||7|
|Journal||Acta physiologica Academiae Scientiarum Hungaricae|
|Publication status||Published - Dec 1 1974|
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